RecruitingNCT07432347

Decoding Epigenetic Mechanisms Driving Immune Evasion in Liver Cancer With Omics Approaches

Sponsor

Niguarda Hospital

Enrollment

270 participants

Start Date

Jan 1, 2026

Study Type

OBSERVATIONAL

Conditions

Hepatocarcinoma

Summary

This is a national, observational, retrospective, cross-sectional, non-profit study focused on patients with HCC. The study aims to characterize the expression and function of novel noncoding regulatory transcripts, including those containing TEsin the microenvironment of liver tumors, with emphasis on their role in T cell dysfunction.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study investigates the biological and genetic changes in liver cancer (hepatocellular carcinoma) that help the tumour hide from the immune system, using advanced laboratory analysis of tumour samples. **You may be eligible if...** - You have been diagnosed with liver cancer (hepatocellular carcinoma) through imaging or biopsy - Fresh tumour tissue or stored tumour samples are available for analysis - You are able to understand and sign a consent form - Your hepatitis B and C status is known **You may NOT be eligible if...** - No tumour tissue is available for the study - You are unable or unwilling to provide informed consent Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

GENETICCollection of tumor tissue (Fresh or/and archival FFPE), blood samples

NGS, immunofluorescence analyses, transcriptional and immunophenotypic analyzes, scRNAseq, ChIP-seq/ATAC-seq, DNA methylation, single-cell transcriptomic and TCR sequencing

Locations(1)

ASST GOM Niguarda

Milan, Lombardy, Italy

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NCT07432347

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