RecruitingNCT07433257

The Effect of Local Corticosteroid Injection in Carpal Tunnel Syndrome Patients With Type 2 Diabetes

The Effect of Local Corticosteroid Injection on Electrophysiological and Ultrasonographic Findings in Carpal Tunnel Syndrome Patients With Type 2 Diabetes

Sponsor

Haydarpasa Numune Training and Research Hospital

Enrollment

60 participants

Start Date

Mar 1, 2026

Study Type

OBSERVATIONAL

Conditions

Type 2 Diabetes Mellitus (T2DM)Carpal Tunnel Syndrome (CTS)

Summary

Our study was planned as a prospective observational study aiming to compare the post-intervention recovery process between patients with carpal tunnel syndrome (CTS) and diabetes mellitus and patients with idiopathic carpal tunnel syndrome without diabetes mellitus. Patients who presented to the Physical Medicine and Rehabilitation outpatient clinic with clinical symptoms consistent with carpal tunnel syndrome and who were diagnosed with mild to moderate carpal tunnel syndrome based on electrophysiological findings and who received corticosteroid + local anesthetic injection will be included in the study. Data from patients who meet the inclusion and exclusion criteria will be included in the study. Patients' demographic and clinical data will be recorded. Records will be taken before treatment and at 4 and 12 weeks after treatment.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria11

Carpal Tunnel Syndrome with Type 2 Diabetes Mellitus Group (Group 1):
Age between 18 and 75 years
Presence of clinical symptoms compatible with carpal tunnel syndrome (e.g., pain, paresthesia, numbness) for at least 3 months
Patients diagnosed with mild-to-moderate carpal tunnel syndrome based on electrophysiological findings
Diagnosis of type 2 diabetes mellitus
Regulated blood glucose levels, defined as hemoglobin A1c (HbA1c) < 7%
Idiopathic Carpal Tunnel Syndrome Group (Group 2):
Age between 18 and 75 years
Presence of clinical symptoms consistent with carpal tunnel syndrome (e.g., pain, paresthesia, numbness) for at least 3 months
Patients diagnosed with mild-to-moderate carpal tunnel syndrome based on electrophysiological findings
No diagnosis of diabetes mellitus

Exclusion Criteria11

Severe carpal tunnel syndrome based on electrophysiological findings
Presence of polyneuropathy, cervical radiculopathy, brachial plexopathy, or thoracic outlet syndrome
Uncontrolled blood glucose levels in the diabetic group (hemoglobin A1c ≥ 7%)
Presence of another systemic disease, other than diabetes mellitus, that may cause carpal tunnel syndrome
Presence of a rheumatological disease
History of wrist surgery
Less than 6 months since a local corticosteroid injection for carpal tunnel syndrome
Less than 3 months since completion of a physical therapy program for carpal tunnel syndrome
Infection at the intended injection site
Presence of malignancy
Pregnancy

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Interventions

DRUG1 mL 40 mg [40 mg/mL] triamcinolone acetonide + 1 mL 2% lidocaine hydrochloride

Both groups will receive an injection containing 1 mL of 40 mg \[40 mg/mL\] triamcinolone acetonide + 1 mL of 2% lidocaine hydrochloride, administered using the 'ulnar in-plane' technique under ultrasound guidance.