RecruitingPhase 1Phase 2NCT07436949

A Study of BBT002 in Healthy Volunteers (HVs) and in Patients With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid Asthma

A Randomized, Double-Blind, Placebo-controlled, Single- and Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics,Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) With or Without Comorbid Asthma

Sponsor

Bambusa Therapeutics

Enrollment

64 participants

Start Date

Mar 2, 2026

Study Type

INTERVENTIONAL

Conditions

Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

Summary

This study is a randomized, double-Blind, placebo-controlled, Single and Multiple-ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, Pharmacodynamics and Clinical Activity of BBT002 in Healthy Volunteers and Participants with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) with or without Asthma.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called BBT002 and a drug called Placebo for people with chronic rhinosinusitis with nasal polyps (crswnp). The study is currently recruiting participants at 12 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGBBT002

BBT002 will be administered.

DRUGPlacebo

Placebo will be administered

Locations(12)

People's Hospital of Peking University

Beijing, Beijing Municipality, China

The Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China

Xiangya Hospital of Central South University

Changsha, Hunan, China

Jiangsu Province Hospital

Nanjing, Jiangsu, China

The Second Hospital of Shandong Province

Jinan, Shandong, China

Qingdao University Hospital

Qingdao, Shandong, China

The Affiliated Yuhuangding Hospital of Qingdao University

Yantai, Shandong, China

Zibo Hospital of Shandong University

Zibo, Shandong, China

Renji Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, China

The Second Hospital of Chengdu City

Chengdu, Sichuang, China

Zhejiang People's Hospital

Hangzhou, Zhejiang, China

The Second Affiliated Hospital of Wenzhou Medical University

Wenzhou, Zhejiang, China

View Full Details on ClinicalTrials.gov

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NCT07436949

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