RecruitingPhase 1NCT07437079

A Study to See How Safe a New Medicine (NNC6989-0001) is in Healthy People Living With Overweight or Obesity

A First Human Dose Study Investigating Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of Single and Multiple Ascending Doses of NNC6989-0001 in Healthy Participants With Overweight or Obesity


Sponsor

Novo Nordisk A/S

Enrollment

132 participants

Start Date

Feb 24, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This study is testing a new medicine, NNC6989-0001, to test it is safe and tolerable for healthy people living with overweight or obesity. NNC6989-0001 is still being tested in studies and is not yet available for prescription by doctors. In this study, participants will receive either NNC6989-0001 or a placebo; which treatment each participant receives will be decided by chance.


Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This Phase 1 study is testing a new experimental weight-loss medicine called NNC6989-0001 in healthy adults with overweight or obesity to assess its safety and tolerability. The drug has not yet been approved for prescription and is being studied in two parts — single doses and then multiple doses over time — with participants receiving either the medicine or a placebo. Non-pregnant adults aged 18 to 55 with a BMI between 25 and 35 (single dose) or 25 to 40 (multiple dose) who are otherwise healthy may be eligible, provided they have not recently used GLP-1 receptor agonist medications or undergone significant weight changes. Participation involves receiving injections of the medicine or placebo and attending clinic visits with blood tests and health monitoring throughout the study. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGNNC6989-0001

Participants assigned to the active intervention receive NNC6989-0001

DRUGPlacebo (NNC6989-0001)

Participants assigned to the placebo, receive placebo matched in appearance to the active drug.


Locations(1)

ICON Early Phase Services, LLC

Lenexa, Kansas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07437079


Related Trials