RecruitingPhase 2NCT07442747

Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

Neural Mechanisms Underlying the Benefits of Aerobic Exercise in Advanced Parkinson's Disease

Sponsor

The Cleveland Clinic

Enrollment

36 participants

Start Date

Jul 8, 2026

Study Type

INTERVENTIONAL

Conditions

Deep Brain Stimulation Parkinson's Disease

Summary

This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a behavioral approach called Exercise for people with deep brain stimulation and parkinson's disease. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALExercise

Participants will complete an eight-week control period followed by an eight-week cycling program. They will complete 3 sessions per week in-person with a member of the study team, for a total of 24 exercise sessions.