RecruitingPhase 1NCT07444619
A Phase I Study of Pazopanib in Combination With Trabectedin, Ipilimumab and Nivolumab (TraPIN) in Pediatric and Young Adult Patients With Recurrent Soft Tissue Sarcomas
Sponsor
M.D. Anderson Cancer Center
Enrollment
18 participants
Start Date
Jun 9, 2026
Study Type
INTERVENTIONAL
Conditions
Summary
The goal of this study is to build on the experience of the SAINT trial by evaluating the safety and efficacy of the addition of pazopanib to their published chemotherapy regimen.
Eligibility
Min Age: 1 YearMax Age: 30 Years
Plain Language Summary
Simplified for easier understanding
This clinical trial is studying a drug called Ipilimumab, a drug called Nivolumab, and others for people with soft tissue sarcomas. The study is currently recruiting participants at 1 location. People eligible for this study include aged 1 Year to 30 Years.
This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
DRUGPazopanib
Given by mouth
DRUGTrabectedin
Given by IV
DRUGIpilimumab
Given by IV
DRUGNivolumab
Given by IV
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07444619
Related Trials
A Study of SHY-ONC6, a Novel Proteasome Inhibitor, in Adults With Advanced or Metastatic Solid Tumors
NCT077053343 locations
A Phase I Trial of Combination Gemcitabine and Nab-Sirolimus in Advanced Leiomyosarcomas or Advanced Soft-Tissue Sarcomas With TSC2 or TSC1 Loss-of-function Mutations or Deletions
NCT063084191 location
IO Combined With AI as First-line Treatment for Patients With Soft Tissue Sarcoma(TAIS)
NCT068499861 location
CINSARC Signature and Correlation With Hemotherapy Efficacy in Soft-tissue Sarcomas. A Biomarker Study.
NCT0278938410 locations
Hypofractionated Radiotherapy Followed by Surgical Resection in the Treatment of Soft Tissue Sarcomas
NCT045060081 location