RecruitingNot ApplicableNCT07451496

PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)

Sponsor

National University of Singapore

Enrollment

20 participants

Start Date

Sep 29, 2025

Study Type

INTERVENTIONAL

Conditions

ageing

Summary

As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .

Eligibility

Min Age: 50 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study tests an 8-week personalized health program for adults aged 50–80 that combines lifestyle changes (exercise, dietary adjustments) with targeted supplements to address the biological processes of aging — such as inflammation, muscle loss, and cognitive decline. The goal is to see whether this tailored approach can measurably improve physical fitness, brain function, and immune health. Eligible participants must be relatively healthy, not regularly exercising, and score below average on fitness and cognitive tests. The study takes place at the National University of Singapore and involves exercise sessions, supplement intake, and assessments of strength, cognition, blood markers, and digital health trackers. This summary was prepared to help patients understand the study in plain language.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSleep and dietary counseling

Sleep hygiene education and individualized dietary recommendations delivered throughout the intervention period.

OTHERSupervised exercise and exergaming program

Supervised dual-task cognitive-physical training with an exergaming component conducted three times per week, 60 minutes per session.

BEHAVIORALMotivational interviewing

Structured motivational interviewing sessions aimed at improving adherence to lifestyle and supplementation interventions conducted two times throughout the study.

DIETARY_SUPPLEMENTWhey protein

Daily whey protein supplementation (GOLD STANDARD 100% ISOLATE, Optimum Nutrition) provided using a standard 30 g scoop (\~25 g protein). Dosage based on body weight: 40-59 kg: 1 scoop/day 60-89 kg: 1.5 scoops/day ≥90 kg: 2 scoops/day

DIETARY_SUPPLEMENTCreatine Monohydrate

Daily creatine supplementation (Micronized Creatine Monohydrate, Optimum Nutrition; 1.25 g per capsule). Dosage based on body weight: 40-59 kg: 4 capsules/day 60-89 kg: 6 capsules/day ≥90 kg: 8 capsules/day

DIETARY_SUPPLEMENTFucoidan

Daily fucoidan supplementation (SIRT6Activator®, DoNotAge.org) at a dose of 2.4 g/day.

DIETARY_SUPPLEMENTUrolithin A

Participants below the 50th percentile for normative muscle mass receive urolithin A (StanYouth™ Urolithin A, Bonerge) at 250 mg/day.

DIETARY_SUPPLEMENTNicotinamide Mononucleotide (NMN)

Participants below the 50th percentile for normative VO₂peak receive NMN (AbinoNutra® NMN, Abinopharm, Inc.) at 300 mg/day.

DIETARY_SUPPLEMENTMultivitamin

Participants below the 50th percentile for normative cognitive performance receive a gender-specific multivitamin (Centrum), 1 tablet daily.

DIETARY_SUPPLEMENTErgothioneine

At the midpoint of the intervention (1 month), participants may receive ergothioneine (Dr.Ergo® L-ergothioneine) at 25 mg three times per week based on individual response.