An Evaluation of the Safety and Efficacy of TSND-201 for the Treatment of PTSD (EMPOWER-1)

This study (called EMPOWER-1) tests the safety and effectiveness of a new drug called TSND-201 for adults with post-traumatic stress disorder (PTSD)—a condition that develops after experiencing a traumatic event and involves symptoms like flashbacks, nightmares, severe anxiety, and emotional numbness. Participants must have had PTSD symptoms for at least 6 months and have already tried at least one other treatment. **You may be eligible if...** - You have a current diagnosis of PTSD with symptoms lasting at least 6 months - You have previously tried at least one medication for PTSD or completed trauma-focused therapy - You are otherwise in good general health - You can complete interviews and written questionnaires **You may NOT be eligible if...** - You have a primary diagnosis of another psychiatric disorder - Your BMI is below 18 or 40 or above (very underweight or very obese) - You are unable to avoid nicotine use for at least 8 hours before assessments - You have a significant cardiovascular or brain-related health history (including uncontrolled high blood pressure) - You are taking certain prohibited medications Talk to your doctor to see if this trial is right for you.