Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.
Robert Bosch Medical Center
100 participants
Feb 1, 2025
OBSERVATIONAL
Conditions
Summary
The hypothesis is that renal function will improve following tricuspid valve intervention. A reduction in renal biomarkers is also expected. Furthermore, based on previous assessments, it is anticipated that there will be an improvement in volume status (reduced edema), symptom burden, and physical capacity in patients. Additionally, the study will assess the impact of the intervention on functional parameters such as motor capacity, physical activity, performance of activities of daily living, and ultimately, participation and quality of life.
Eligibility
Inclusion Criteria4
- Severe symptomatic tricuspid valve insufficiency and referral for TriClip/TricValve screening
- Completed 18th year of life
- Ability to consent
- Able to walk short distances with aids
Exclusion Criteria5
- Dialysis-dependent/terminal kidney disease
- Inability to comply with study-associated assessments (e.g., existing dementia)
- Severe anemia (Hb \<7 g/dl)
- Tricuspid valve intervention with palliative intent and likely imminent death
- Lack of consent
Interventions
Routine intervention, observational
Locations(1)
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NCT07464106