Tricuspid Regurgitation Clinical Trials

51 recruitingLast updated: June 18, 2026

There are 51 actively recruiting tricuspid regurgitation clinical trials across 27 countries. Studies span Not Applicable. Top locations include New York, New York, United States, Portland, Oregon, United States, Atlanta, Georgia, United States. Updated daily from ClinicalTrials.gov.


Tricuspid Regurgitation Trials at a Glance

51 actively recruiting trials for tricuspid regurgitation are listed on ClinicalTrialsFinder across 6 cities in 27 countries. The largest study group is Not Applicable with 26 trials, with the heaviest enrollment activity in New York, Portland, and Atlanta. Lead sponsors running tricuspid regurgitation studies include LMU Klinikum, Abbott Medical Devices, and Cardiovalve Ltd..

Browse tricuspid regurgitation trials by phase

Treatments under study

About Tricuspid Regurgitation Clinical Trials

Looking for clinical trials for Tricuspid Regurgitation? There are currently 41 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Tricuspid Regurgitation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Tricuspid Regurgitation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 51 trials

Recruiting
Not Applicable

Safety and Effectiveness Study of DragonFly-T System for Severe Tricuspid Regurgitation

Tricuspid Regurgitation
Hangzhou Valgen Medtech Co., Ltd236 enrolled2 locationsNCT05556460
Recruiting
Not Applicable

EFS of the DUO System for Tricuspid Regurgitation

Tricuspid RegurgitationHeart Valve DiseasesTricuspid Valve Insufficiency+1 more
CroiValve Limited15 enrolled15 locationsNCT05913908
Recruiting
Not Applicable

Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial

Tricuspid RegurgitationTricuspid Valve InsufficiencyTricuspid Valve Disease
Edwards Lifesciences1,270 enrolled79 locationsNCT04097145
Recruiting

Efficacy of Early Rhythm Control in AF With TR Patients

Atrial Fibrillation (AF)Tricuspid Regurgitation (TR)
Samsung Medical Center5,800 enrolled1 locationNCT07607093
Recruiting

Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study

Atrial Fibrillation (AF)Tricuspid Regurgitation (TR)
Centro Cardiologico Monzino66 enrolled1 locationNCT07617974
Recruiting

Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

Tricuspid RegurgitationValvular Heart DiseaseMitral Regurgitation
Abbott Medical Devices550 enrolled17 locationsNCT04761120
Recruiting
Not Applicable

TARGET 2.0 Study: Safety and Performance of the Cardiovalve TR Replacement System

Tricuspid Regurgitation
Cardiovalve Ltd.150 enrolled1 locationNCT07334691
Recruiting
Not Applicable

TRICuspid Intervention and Invasive Hemodynamic Monitoring in Heart Failure

Heart Failure With Severe Tricuspid Regurgitation
LMU Klinikum45 enrolled2 locationsNCT07442903
Recruiting

Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

Atrial FibrillationFunctional Mitral RegurgitationFunctional Tricuspid Regurgitation
Barts & The London NHS Trust141 enrolled1 locationNCT05920824
Recruiting

DELINEATE-Prospective

Valvular Heart DiseaseValve Disease, AorticAortic Stenosis+3 more
Columbia University50 enrolled1 locationNCT07197736
Recruiting
Not Applicable

Robotic Transjugular Transcatheter Tricuspid Valve Replacement

Tricuspid Regurgitation (TR)Transcatheter Valve ReplacementValvular Heart Diseases
Prince of Wales Hospital, Shatin, Hong Kong10 enrolled1 locationNCT07516145
Recruiting

TriClip Japan Post-Approval Study

Tricuspid Regurgitation
Abbott Medical Devices250 enrolled1 locationNCT07509658
Recruiting
Not Applicable

Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)

Tricuspid RegurgitationTricuspid Valve DiseaseTricuspid Valvular Disorders
VDyne, Inc.30 enrolled11 locationsNCT05848284
Recruiting

Berlin Registry of Right Heart Interventions

Tricuspid RegurgitationPulmonary Regurgitation
Charite University, Berlin, Germany200 enrolled1 locationNCT04570163
Recruiting

Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on Renal Integrity and Function, as Well as on Physical Function and Activity in Older Adults.

FrailtyTricuspid RegurgitationCardio-Renal Syndrome+1 more
Robert Bosch Medical Center100 enrolled1 locationNCT07464106
Recruiting
Not Applicable

TTVR Early Feasibility Study

Tricuspid Regurgitation
Medtronic Cardiovascular150 enrolled20 locationsNCT04433065
Recruiting
Not Applicable

A Prospective, Multicenter, Randomized Controlled Clinical Trial of Transcatheter Tricuspid Valve Clipping Systems.

Severe or Greater Tricuspid Regurgitation
Shanghai Huihe Medical Technology Co., Ltd132 enrolled1 locationNCT07433504
Recruiting
Not Applicable

Acute Safety and Efficacy of the Pivot Bridge System for Functional Tricuspid Regurgitation

Tricuspid Regurgitation Functional
Tau-MEDICAL Co., Ltd.20 enrolled4 locationsNCT07385625
Recruiting
Not Applicable

"TARGET Study": Safety and Performance of the Cardiovalve TR Replacement System

Tricuspid Regurgitation
Cardiovalve Ltd.100 enrolled7 locationsNCT05486832
Recruiting
Not Applicable

Band Versus Ring for Tricuspid Regurgitation

Tricuspid Regurgitation
Nanjing Medical University300 enrolled1 locationNCT04093297