RecruitingNot ApplicableNCT07466966

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis: A Multicenter Randomized Controlled Trial (MINST vs NSPT)

Sponsor

St. Anne's University Hospital Brno, Czech Republic

Enrollment

106 participants

Start Date

Jan 1, 2026

Study Type

INTERVENTIONAL

Conditions

Peri-implantitis Periodontitis Non-surgical Periodontal Therapy

Summary

This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients diagnosed with peri-implantitis. The study investigates clinical outcomes, radiographic bone levels, patient-reported outcomes, and treatment time over 12 months.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

Age ≥18
Peri-implantitis diagnosis (PPD \>6 mm, BOP+, bone loss ≥3 mm)
Accessible implant surface without removing suprastructure
FMPS \<30%, FMBS \<30-35%

Exclusion Criteria8

Antibiotics in last 3 months
Pregnancy/lactation
Uncontrolled diabetes (HbA1c ≥7)
Long-term SPIC (\>2 years)
Previous implant therapy \<12 months
Smoking/vaping in last 12 months
Hopeless implant
Need for adjunctive antibiotics

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Interventions

PROCEDURENon-Surgical Peri-implant Therapy (NSPT)

Standard mechanical debridement of the peri-implant pocket performed under local anesthesia. Treatment includes supra- and submucosal ultrasonic debridement using stainless-steel ultrasonic tips, followed by mechanical curettage of granulation tissue with steel curettes (Columbia 4R/4L). Soft-tissue curettage is performed from the inner aspect of the peri-implant pocket. No time restriction is imposed; the operator works until the implant surface is clinically clean.

PROCEDUREMinimally-Invasive Non-Surgical Therapy (MINST)

Minimally invasive ultrasonic debridement performed under local anesthesia using exclusively thin, non-diamond ultrasonic tips (Satalec PS3, EMS PS, PS, PL1, PL2; Siroperio 1/2/3/7; Woodpecker P3; Acteon 10Z). Treatment is carried out under ≥3× magnification with emphasis on tissue preservation. The operator aims to achieve a stable blood clot emerging from the peri-implant pocket after instrumentation. No curettes or sharp instruments are used.