Peri-implantitis Clinical Trials

34 recruitingLast updated: May 21, 2026

There are 34 actively recruiting peri-implantitis clinical trials across 19 countries. Studies span Not Applicable, Early Phase 1, Phase 4. Top locations include Sant Cugat del Vallès, Barcelona, Spain, Stockholm, Sweden, Ankara, Turkey (Türkiye). Updated daily from ClinicalTrials.gov.


Peri-implantitis Trials at a Glance

34 actively recruiting trials for peri-implantitis are listed on ClinicalTrialsFinder across 6 cities in 19 countries. The largest study group is Not Applicable with 22 trials, with the heaviest enrollment activity in Sant Cugat del Vallès, Stockholm, and Ankara. Lead sponsors running peri-implantitis studies include Gazi University, Ramón Pons Calabuig, and Universitat Internacional de Catalunya.

Browse peri-implantitis trials by phase

About Peri-implantitis Clinical Trials

Looking for clinical trials for Peri-implantitis? There are currently 37 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Peri-implantitis trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Peri-implantitis clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 34 trials

Recruiting

Investigation of Macrophage Polarization in Peri-implant Health and Peri-implantitis

Peri-implantitis
Biruni University120 enrolled1 locationNCT07569432
Recruiting
Not Applicable

Crown Removal in Non-Surgical Peri-Implantitis Therapy: A Randomized Trial

Peri-implantitis
G. d'Annunzio University36 enrolled1 locationNCT07391202
Recruiting
Not Applicable

Peri-implantitis Implantoplasty Treatment

Peri-implantitisPeri-implant mucositis
University of Oslo35 enrolled2 locationsNCT04052373
Recruiting

Long-term Stability of Peri-implantitis Treatments: a 3-year Clinical Evaluation

Peri-implantitis
Ramón Pons Calabuig34 enrolled2 locationsNCT07208643
Recruiting
Not Applicable

Peri-implantitis Management: Surgical and Maintenance Outcomes

Peri-implantitis
University of Pittsburgh44 enrolled1 locationNCT07550127
Recruiting
Not Applicable

Comparison of the Effectiveness of Two Different Surgical Therapeutic Protocols of Peri-implantitis

Peri-implantitisPeri-implant health
National and Kapodistrian University of Athens45 enrolled1 locationNCT05899933
Recruiting
Not Applicable

Surgical Treatment of Peri-implantitis With Adjunctive Application of Platelet Rich Fibrin (PRF)

Peri-implantitisPlatelet-rich FibrinBone Resorption
University of Bern40 enrolled1 locationNCT06679283
Recruiting
Not Applicable

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Peri-implantitisPeriodontitisNon-surgical Periodontal Therapy
St. Anne's University Hospital Brno, Czech Republic106 enrolled1 locationNCT07466966
Recruiting
Not Applicable

Adjunctive Keratinized Mucosa Augmentation in Peri-Implantitis

Peri-implantitisSoft Tissue Augmentation at Dental Implants
Gazi University30 enrolled1 locationNCT07471386
Recruiting
Not Applicable

Immediate Versus Delayed Surgical Reconstruction of Peri-implantitis Intra-bony Defects.

Peri-implantitis
University of Michigan40 enrolled1 locationNCT07325747
Recruiting

Periodontitis and Inflammation

Peri-implantitisPeriodontitis
Assistance Publique - Hôpitaux de Paris219 enrolled2 locationsNCT04831060
Recruiting
Not Applicable

Efficacy of Photodynamic Therapy in the Non-Surgical Treatment of Peri-Implantitis

Peri-implantitis
Egas Moniz - Cooperativa de Ensino Superior, CRL40 enrolled1 locationNCT07191522
Recruiting
Not Applicable

Peri-implantitis Treatment With Chitosan Brush

Peri-implantitis
Hacettepe University60 enrolled1 locationNCT06830200
Recruiting
Not Applicable

Natural Bioactive Gel for Peri-Implantitis

Peri-implantitisDental ImplantsNon-surgical Periodontal Therapy
University of Pavia20 enrolled1 locationNCT07088679
Recruiting
Not Applicable

Investigation of Biofilm Formation on Temporary push-on Rings of Implant Crowns

Peri-implantitisOral BiofilmDental Plaque
University Hospital, Basel, Switzerland33 enrolled1 locationNCT05122897
Recruiting
Not Applicable

Immunological-Clinical Evaluation of the Etiopathogenesis of Peri-Implantitis

Peri-implantitis
Wroclaw Medical University100 enrolled1 locationNCT07012915
Recruiting

The Study on the Accuracy of Peri-implant Probing and Related Influencing Factors

Peri-implantitisDiagnosis
The Dental Hospital of Zhejiang University School of Medicine83 enrolled1 locationNCT07004517
Recruiting
Not Applicable

Impact of Non-surgical Periodontal Therapy in the Improvement of Early Endothelial Dysfunction in Subjects With Peri-implantitis and Peri-implant Mucositis

Peri-implantitisPeri-implant mucositisAtherosclerosis+1 more
University of Catania90 enrolled1 locationNCT05906810
Recruiting
Not Applicable

Reconstructive Treatment of Peri-implantitis With Combined Defects

Peri-implantitis
Gazi University60 enrolled1 locationNCT06957652
Recruiting

Using biological markers in saliva to diagnose and monitor treatment for gum disease around dental implants

Peri-implantitisPeri-implant disease
School of Dentistry - University of Queensland96 enrolled1 locationACTRN12625000362493