RecruitingNot ApplicableNCT07469384

Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

Sensory Contributions to Third Visual Pathway Dysfunction in Schizophrenia: Correlation and Causation

Sponsor

Nathan Kline Institute for Psychiatric Research

Enrollment

120 participants

Start Date

Feb 1, 2026

Study Type

INTERVENTIONAL

Conditions

Schizo Affective Disorder SCHIZOPHRENIA 1 (Disorder)

Summary

This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability. tDCS is a type of non-invasive brain stimulation in which low level currents are applied over the scalp to influence underlying brain function. In schizophrenia, impaired ability to detect facial motion has been shown to contribute to impaired FER, which, in turn, leads to difficulties in social cognition and poor social outcome. The study will use both fMRI and EEG to measure brain function while participants view moving dot and dynamic face stimuli. Analyses will compare changes in fMRI and EEG activity in individuals receiving active vs. sham stimulation.

Eligibility

Min Age: 18 YearsMax Age: 55 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) — which sends a very weak electrical current through the scalp — can improve vision-related problems in people with schizophrenia or schizoaffective disorder. **You may be eligible if...** - You are between 18 and 55 years old - You have a confirmed diagnosis of schizophrenia or schizoaffective disorder - Your IQ is above 70 - You are currently taking psychiatric medication within the standard recommended range - You do not have a current substance use disorder **You may NOT be eligible if...** - You have a significant neurological condition or history of serious head injury - You have a physical health condition or significant hearing or vision problems that might interfere with the study - You cannot have an MRI (e.g., due to metal implants, severe claustrophobia, or pregnancy) - You have metal implants, a pacemaker, a history of seizures, or a history of stroke (which would make tDCS unsafe) - You have significant current suicidal thoughts - You have a moderate or severe substance use disorder in the past 12 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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