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RecruitingNCT07472049

Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging

Sponsor

University of Edinburgh

Enrollment

100 participants

Start Date

Jul 31, 2025

Study Type

OBSERVATIONAL

Conditions

Peripheral Arterial DiseaseChronic Limb Threatening Ischemia

Summary

The goal of this observational study is to characterise the relationships between inflammation, microcalcification and thrombus activity in atherosclerotic plaques in peripheral and systemic vascular territories in patients with symptomatic peripheral arterial disease.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Whole body CT angiogram, Whole body [18F]GP1 PET-CT, and others for people with chronic limb threatening ischemia and peripheral arterial disease. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

RADIATIONWhole body [68Ga]DOTATATE PET-CT

Targeting vascular inflammation

RADIATIONWhole body [18F]GP1 PET-CT

Targeting thrombus activity

RADIATIONWhole body [18F]NaF PET-CT

Targeting vascular microcalcification

RADIATIONWhole body CT angiogram

To determine anatomical and morphological atherosclerotic plaque characteristics

Locations(1)

Royal Infirmary of Edinburgh

Edinburgh, Midlothian, United Kingdom

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NCT07472049

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