RecruitingNCT07473518

Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy

Sponsor

IRCCS Azienda Ospedaliero-Universitaria di Bologna

Enrollment

2,550 participants

Start Date

Jul 30, 2025

Study Type

OBSERVATIONAL

Conditions

Thyroid Carcinoma Pediatric Cancer

Summary

This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.

Eligibility

Min Age: 10 YearsMax Age: 43 Years

Inclusion Criteria11

For the group of oncologic patients who underwent radiotherapy:
Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018;
Age at the time of radiotherapy \< 18 years;
Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna;
Obtained informed consent
For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:
No history of exposure to ionizing radiation;
No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes);
Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna;
Age at the time of the thyroid ultrasound \< 18 years;
Obtained informed consent

Exclusion Criteria4

For the group of oncologic patients who underwent radiotherapy:
Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer.
For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC:
None.

Locations(2)

UO Medicina Nucleare - IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, Italy

UOC Pediatria - IRCCS Azienda Ospedaliero-Universitaria di Bologna

Bologna, Italy

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT07473518

Related Trials

Proof-of-Concept Study of the SNOEZELEN Device on Anxiety Symptoms in Patients Hospitalized for Chemotherapy in a Pediatric Oncology Department

NCT072025071 location

Safety and Efficacy of Cyclophosphamide, Sorafenib, Bevacizumab, and Atezolizumab in Pediatric Solid Tumor Patients

NCT054683592 locations