RecruitingNCT07485621

LFP-based Parameter Prediction in DBS for Parkinson's Disease

Assessing the Relation Between Subcortical LFPs and DBS Parameter Selection in Parkinson's Disease - a Prospective Study

Sponsor

Loes Laurijssen

Enrollment

40 participants

Start Date

Mar 5, 2026

Study Type

OBSERVATIONAL

Conditions

Parkinson's Disease (PD)

Summary

The goal of this observational study is to assess whether deep brain stimulation (DBS) contact selection in Parkinson's disease could be informed by subcortical local field potential (LFP) recordings. The main question it aims to answer is: Aligns stimulation contact selection based on subcortical LFP recordings with clinically optimized contact selection? Participants will undergo LFP recordings that are part of standard clinical care during their routine hospital visits.

Eligibility

Min Age: 18 Years

Inclusion Criteria5

Voluntary written informed consent of the participant
At least 18 years of age at the time of signing the Informed Consent Form (ICF)
Diagnosis of idiopathic Parkinson's disease according to the clinical diagnostic criteria of the Movement Disorder Society (MDS)
Eligible for DBS to treat refractory PD motor symptoms, as based on multidisciplinary DBS screening
Have sufficient understanding of the Dutch and French language to participate in the study