RecruitingPhase 4NCT07508124

Topical Steroids to Prevent Recurrent Urinary Tract Infections in Uncircumcised Male Infants: a Pilot Study

Topical Steroids to Prevent Recurrent Urinary Tract Infections in Uncircumcised Male Infants With a First Febrile Urinary Tract Infection: a Multi-center Pilot Study


Sponsor

Baylor College of Medicine

Enrollment

40 participants

Start Date

Apr 1, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this smaller clinical trial is to evaluate the study design of this research to help prepare for a larger research study in the future. The future larger study would focus on whether steroid cream can reduce recurrent urinary tract infections in male infants, who are not circumcised. Male infants, who are enrolled in this study, would receive either the steroid cream or a placebo cream (a look alike cream without steroids). The cream would be applied twice a week for four weeks. Then there would be two follow up visits with the research team to measure whether the infant experienced any urinary tract infections and to measure parent perceptions of their experience participating in the study.


Eligibility

Sex: MALEMin Age: 0 MonthsMax Age: 5 Months

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo cream and a drug called betamethasone valerate 0.1% cream for people with urinary tract infection. The study is currently recruiting participants at 3 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGbetamethasone valerate 0.1% cream

Steroid cream applied to the foreskin and glans twice a day for four weeks.

DRUGPlacebo cream

Placebo cream is applied to the foreskin and glans twice a day for four weeks.


Locations(3)

Texas Children's Hospital Main campus

Houston, Texas, United States

Texas Children's Hospital West Campus

Katy, Texas, United States

Seattle Children's Hospital

Seattle, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT07508124


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