Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes
Integrated Assessment of Pancreatic Dysfunction in Patients With Type 2 Diabetes: a Cross-sectional Study Protocol
West Kazakhstan Marat Ospanov Medical University
310 participants
Jul 7, 2025
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to better understand how the pancreas works in adults with type 2 diabetes. The study focuses on both hormone production (endocrine function) and digestive function (exocrine function) of the pancreas. The main questions it aims to answer are: * Can problems with the pancreas help identify a different type of diabetes called pancreatogenic diabetes? * How are blood markers and pancreas structure related to pancreatic function? Participants will: * Have blood tests to measure glucose, insulin, and other markers * Provide a stool sample to assess digestive function * Undergo an ultrasound examination of the pancreas * Answer questions about digestive symptoms The study will take place during a single visit in outpatient clinics.
Eligibility
Inclusion Criteria4
- adult patients of Kazakh nationality aged 18 to 74 years
- diagnosis of T2DM established according to ADA criteria and documented in medical records
- disease duration ≤5 years
- absence of ketoacidosis episodes within the last 6 months
Exclusion Criteria8
- positive anti-glutamic acid decarboxylase antibodies (anti-GAD65);
- acute or chronic infections affecting metabolic status within the previous 4 weeks;
- any history of malignant neoplasms;
- pregnancy or lactation;
- previously diagnosed type 1 diabetes mellitus or other specific types of diabetes;
- severe decompensated chronic diseases;
- conditions associated with systemic fibrosis (e.g., liver cirrhosis or autoimmune diseases);
- refusal to participate.
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07512934