Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery
The Analgesic Effect of Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery: A Randomized Double-Blinded Dose-Finding Trial
Cairo University
120 participants
Mar 1, 2025
INTERVENTIONAL
Conditions
Summary
This study aims to compare the duration of analgesia (as the primary outcome) and adverse effects (as the secondary outcome) after intrathecal administration of dexmedetomidine with hyperbaric bupivacaine to patients undergoing knee orthopedic surgery.
Eligibility
Inclusion Criteria3
- Age from 18 to 65 years.
- American Society of Anesthesiologists (ASA) physical status I-II.
- Male patients scheduled for knee orthopedic surgery.
Exclusion Criteria5
- Patients with psychiatric disorders.
- History of drug addiction.
- Contraindication for regional anesthesia.
- History of hypersensitivity to the study drugs.
- Previous administration of opioids and/or other central nervous system depressants during current hospital admission.
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Interventions
Patients will receive intrathecal hyperbaric bupivacaine 15 mg, supplemented with dexmedetomidine 4 μg.
Patients will receive intrathecal hyperbaric bupivacaine 15 mg, supplemented with dexmedetomidine 8 μg.
Patients will receive intrathecal hyperbaric bupivacaine 15 mg, supplemented with dexmedetomidine 12 μg.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT07522736