Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis
Unraveling the Role of JAK1 and JAK2 Pathway in Periodontitis: Drivers of Immunopathology and Possible Therapeutic Targets
University of Chile
30 participants
Jun 1, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to examine JAK1/2 pathway activation in gingival tissues from adults with healthy gingiva and those with inflamed gingiva (periodontitis). The main question it aims to answer is: Is the JAK1/2 pathway overactivated in periodontitis compared to health? Participants with healthy gingiva and periodontitis will donate gingival tissue to study the JAK1/2 pathway. All participants wil receive diagnosis and treatment of the gingival condition.
Eligibility
Inclusion Criteria2
- Adults
- Sistemically healthy
Exclusion Criteria13
- Active Maliganancy
- History of radiation to the head-neck region
- Chemotherapy or radiation within the last 5 years
- History of hepatitis B/C or HIV infection
- Autoimmune diseases
- Diagnosis of diabetes
- Pregnancy or lactation
- More than 3 hospitalizations over the last 3 years
- Use of systemic antibiotics over the last 3 months
- Use of systemic corticosteroids or immunosuppressants over the last 3 months
- Use of cytokine therapy over the last 3 months
- Use of large doses of pre/probiotic supplements over the last 3 months
- Smoke more than 10 cigarettes per day
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Locations(1)
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NCT07536204