RecruitingPhase 2NCT07553442

A Study to Evaluate ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran

A Phase 2, Randomized, Double-blind, Placebo-controlled, Single Dose Study of the Efficacy, Pharmacodynamics, and Safety of ALN-AGT01 RVR in Adult Patients With Mild to Moderate Hypertension Pretreated With Zilebesiran


Sponsor

Alnylam Pharmaceuticals

Enrollment

93 participants

Start Date

Apr 27, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to evaluate the efficacy, pharmacodynamics (PD), and safety of ALN-AGT01 RVR in participants with mild to moderate hypertension pretreated with zilebesiran.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called ALN-AGT01 RVR, a drug called Placebo, and others for people with hypertension. The study is currently recruiting participants at 3 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGALN-AGT01 RVR

ALN-AGT01 RVR will be administered subcutaneously (SC)

DRUGPlacebo

Placebo will be administered SC

DRUGZilebesiran

Zilebesiran will be administered SC


Locations(3)

Clinical Trial Site

Lake Forest, California, United States

Clinical Trial Site

Tampa, Florida, United States

Clinical Trial Site

Savannah, Georgia, United States

View Full Details on ClinicalTrials.gov

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NCT07553442


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