RecruitingNot ApplicableNCT07560904

Non-invasive Stimulation of Deep Brain Structures to Modulate Working Memory

Sponsor

Masaryk University

Enrollment

70 participants

Start Date

Mar 1, 2026

Study Type

INTERVENTIONAL

Conditions

Mild Cognitive Impairment (MCI)Older Adults (60 - 85 Years Old)

Summary

A study investigating the effects of non-invasive electrical stimulation of deep brain structures on working memory, attention, and executive functions involved in everyday activities. Currently, there is no effective treatment for impairments in these functions. The study will evaluate the effects of non-invasive electrical stimulation in both healthy older adults and individuals with mild impairment of these functions. The study combines magnetic resonance imaging (MRI) with non-invasive brain stimulation targeting deep brain structures. Its aim is to improve understanding of the neural mechanisms underlying these cognitive functions and their impairments, as well as to explore the mechanisms of non-invasive brain stimulation for potential future therapeutic applications.

Eligibility

Min Age: 60 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Control striatal stimulation, Non-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz), and others for people with mild cognitive impairment (mci) and older adults (60 - 85 years old). The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNon-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (20 Hz)

Striatum will be targeted by using at least two pairs of high-frequency tES with a low-frequency (20 Hz) offset, creating an interference hotspot targeting the deep brain structure (deep-tES).

OTHERControl striatal stimulation

A high-frequency tES without low-frequency offset. It will consist of two oscillatory high-frequency currents without any frequency shifts, which induces similar skin sensations as deep-tES and will be applied just for a ramp-up/ramp-down phases at the beginning of the stimulation and afterwards will be switched off.

OTHERNon-invasive deep brain stimulation of striatum via transcranial temporal interference stimulation (60 Hz)

Striatum will be targeted by using at least two pairs of high-frequency tES with a low-frequency (60 Hz) offset, creating an interference hotspot targeting the deep brain structure (deep-tES).