RecruitingPhase 2NCT07589608

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

A Phase 2b, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and Without Type 2 Diabetes

Sponsor

Eli Lilly and Company

Enrollment

400 participants

Start Date

May 15, 2026

Study Type

INTERVENTIONAL

Conditions

Obesity Overweight

Summary

The main purpose of this study, performed under the master protocol W8M-MC-CWMM (NCT06143956), is to examine the body weight-lowering efficacy and safety of macupatide plus eloralintide compared with placebo in participants with obesity or overweight and without type 2 diabetes. Participation will last about 64 weeks.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Eloralintide, a drug called Macupatide, and others for people with obesity and overweight. The study is currently recruiting participants at 40 locations. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMacupatide

Administered SC

DRUGEloralintide

Administered SC

DRUGPlacebo

Administered SC

Locations(40)

The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

Chandler, Arizona, United States

Headlands Research - Scottsdale

Scottsdale, Arizona, United States

The Institute for Liver Health II dba Arizona Liver Health-Tucson

Tucson, Arizona, United States

NorCal Medical Research, Inc

Greenbrae, California, United States

Velocity Clinical Research, Huntington Park

Huntington Park, California, United States

Peninsula Research Associates

Rolling Hills Estates, California, United States

Diablo Clinical Research, Inc.

Walnut Creek, California, United States

Stamford Therapeutics Consortium

Stamford, Connecticut, United States

New Horizon Research Center

Miami, Florida, United States

Indago Research & Health Center, Inc

Miami Lakes, Florida, United States

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States

Charter Research - Winter Park

Orlando, Florida, United States

Charter Research - Lady Lake

The Villages, Florida, United States

Medical Research Partners

Ammon, Idaho, United States

Great Lakes Clinical Trials - Ravenswood

Chicago, Illinois, United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, United States

Monroe Biomedical Research - Louisville

Louisville, Kentucky, United States

Knownwell

Needham, Massachusetts, United States

Lucida Clinical Trials

New Bedford, Massachusetts, United States

Headlands Research - Detroit

Southfield, Michigan, United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, United States

StudyMetrix Research

City of Saint Peters, Missouri, United States

Clinvest Headlands Llc

Springfield, Missouri, United States

Las Vegas Medical Research

Las Vegas, Nevada, United States

Dent Neurologic Institute

Amherst, New York, United States

Rochester Clinical Research, LLC

Rochester, New York, United States

Medication Management

Greensboro, North Carolina, United States

Monroe Biomedical Research

Monroe, North Carolina, United States

Lucas Research, Inc

Morehead City, North Carolina, United States

Lucas Research, Inc.

New Bern, North Carolina, United States

CTI Clinical Research Center

Cincinnati, Ohio, United States

Tribe Clinical Research, LLC

Greenville, South Carolina, United States

Quality Medical Research

Nashville, Tennessee, United States

IMA Clinical Research Austin

Austin, Texas, United States

FutureSearch Trials of Dallas

Dallas, Texas, United States

PlanIt Research, PLLC

Houston, Texas, United States

Endeavor Clinical Trials

San Antonio, Texas, United States

Texas Valley Clinical Research

Weslaco, Texas, United States

Sovah Clinical Research-River District

Danville, Virginia, United States

Central Washington Health Services Association d/b/a Confluence Health

Wenatchee, Washington, United States

View Full Details on ClinicalTrials.gov

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NCT07589608

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