RecruitingPhase 1NCT07590193

A Trial Evaluating AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

A Phase 1 Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 127 in Healthy Participants and Participants With Type 2 Diabetes Mellitus

Sponsor

Amgen

Enrollment

162 participants

Start Date

Jun 11, 2026

Study Type

INTERVENTIONAL

Conditions

Diabetes Mellitus, Type 2

Summary

The main objective of this trial is to assess the safety and tolerability of AMG 127 as single dose and multiple doses in healthy participants and participants with type 2 diabetes mellitus (T2DM).

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called AMG 127 and a drug called Placebo for people with diabetes mellitus, type 2. The study is currently recruiting participants at 1 location. People eligible for this study include aged 18 Years to 75 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAMG 127

AMG127 will be administered as either a SC injection or as an IV infusion.

DRUGPlacebo

Placebo will be administered as either a SC injection or as an IV infusion.

Locations(1)

Translational Clinical Research LLC

Aventura, Florida, United States

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NCT07590193

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