RecruitingPhase 2NCT07215559

A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

A Phase 2, Parallel-Group, Double-Blind, Placebo-Controlled Study to Investigate Weight Reduction With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight and With Type 2 Diabetes

Sponsor

Eli Lilly and Company

Enrollment

200 participants

Start Date

Oct 16, 2025

Study Type

INTERVENTIONAL

Conditions

Obesity Diabetes Mellitus, Type 2 Overweight

Summary

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing two new weight-loss and blood sugar-lowering drugs — macupatide (LY3532226) and eloralintide (LY3841136) — alone and in combination, in adults with type 2 diabetes who are also overweight or obese. **You may be eligible if...** - You have type 2 diabetes with an HbA1c between 7.5% and 10.5% - You have a BMI of 27 or higher - You have been managing diabetes with diet/exercise, metformin, and/or an SGLT2 inhibitor (a type of diabetes pill) for at least 3 months - Your body weight has been stable in the past 3 months **You may NOT be eligible if...** - You have type 1 diabetes or any form of diabetes other than type 2 - You have had a heart attack, stroke, or heart failure hospitalization in the past 3 months - You have had or plan to have weight loss surgery - You have used GLP-1 receptor agonists or similar weight loss injections in the last 6 months - You have an active or recent cancer (within 5 years) - You have been taking insulin for diabetes in the past year Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMacupatide

Administered SC

DRUGEloralintide

Administered SC

DRUGMacupatide Placebo

Administered SC

DRUGEloralintide Placebo

Administered SC

Locations(38)

Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC

Gilbert, Arizona, United States

Synexus Clinical Research US, Inc.

Phoenix, Arizona, United States

Pima Heart

Tucson, Arizona, United States

SKY Clinical Research Network Group-Brown

Atlanta, Georgia, United States

Teak Research Consults

Lawrenceville, Georgia, United States

AGILE Clinical Research Trials, LLC

Sandy Springs, Georgia, United States

Pivotal Research Solutions

Stonecrest, Georgia, United States

Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, United States

Vector Clinical Trials

Las Vegas, Nevada, United States

Premier Research

Trenton, New Jersey, United States

Mercy Family Clinic

Dallas, Texas, United States

Velocity Clinical Research, Dallas

Dallas, Texas, United States

PlanIt Research, PLLC

Houston, Texas, United States

Aavon Clinical Trials

Richmond, Texas, United States

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Texas Valley Clinical Research

Weslaco, Texas, United States

Kalo Clinical Research

West Valley City, Utah, United States

Eastern Virginia Medical School (EVMS) Medical Group

Norfolk, Virginia, United States

Clinical Research Partners, LLC

Richmond, Virginia, United States

Northwest Clinical Research Center

Bellevue, Washington, United States

Rainier Clinical Research Center

Renton, Washington, United States

Universal Research Group

Tacoma, Washington, United States

Centro de Investigaciones Metabólicas (CINME)

Buenos Aires, Argentina

CENUDIAB

Buenos Aires, Argentina

CEDIC

CABA, Argentina

Instituto de Investigaciones Clínicas Córdoba

Córdoba, Argentina

Clínica Universitaria Reina Fabiola

Córdoba, Argentina

Go Centro Medico San Nicolás

San Nicolás, Argentina

Emeritus Research

Botany, Australia

Core Research Group

Brisbane, Australia

Emeritus Research

Camberwell, Australia

Cornerstone Dermatology

Coorparoo, Australia

Momentum Darlinghurst

Darlinghurst, Sydney, Australia

CDH Research Institute Pty Ltd

Maroochydore, Australia

Momentum Sunshine

Melbourne, Australia

AIM Research

Merewether, Australia

San Juan Bautista School of Medicine - Clinical Research Unit

Caguas, Puerto Rico

Mgcendo Llc

San Juan, Puerto Rico

View Full Details on ClinicalTrials.gov

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NCT07215559

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