Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites
Colorado State University
125 participants
Jan 27, 2026
INTERVENTIONAL
Conditions
Summary
The objective of this study is to determine whether inter-individual differences in the gut microbiome influence exposure to blueberry polyphenol metabolites. We will use pharmacokinetics of blueberry polyphenols after an acute blueberry exposure to group individuals into "metabotypes", groups of individuals based on similarity in their metabolite profiles. We will then use multi-omic approaches to determine whether the gut microbiome predicts an individual's metabotype.
Eligibility
Inclusion Criteria3
- Healthy adults ≥18 years of age
- Able and willing to provide informed consent
- Willing and able to adhere to all study procedures and visit requirements
Exclusion Criteria12
- Age <18 years
- Pregnant or breastfeeding
- Presence of chronic diseases, including but not limited to cardiovascular disease, diabetes, cancer, kidney, liver, gastrointestinal, or pancreatic disease
- Use of medications for chronic diseases that may interfere with study outcomes
- Any condition known to negatively impact nutrient absorption (e.g., inflammatory bowel disease, celiac disease, gastroparesis)
- Anemia (hemoglobin <13.5 g/dL in men or <12.0 g/dL in women)
- Body mass index (BMI) ≤18.5 kg/m²
- Use of antibiotics within the past 2 months
- Recent blood draw within 1 week prior to study participation
- Currently participating in another research study involving a diet or exercise intervention
- Known allergy or contraindication to blueberry products or study procedures
- Unwilling or unable to comply with study requirements
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Interventions
Participants will consume a single oral dose of a standardized blueberry beverage prepared with 22 g of freeze-dried blueberry powder reconstituted in approximately 480 mL of distilled water. The beverage will be consumed in its entirety at the start of the test visit following an overnight fast. This dose is selected to provide a defined quantity of blueberry-derived polyphenols for pharmacokinetic assessment. No additional interventions or comparator treatments will be administered.
Locations(1)
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NCT07607158