Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial
Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial
Rawalpindi Institute of Cardiology
70 participants
May 21, 2026
INTERVENTIONAL
Conditions
Summary
After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.
Eligibility
Inclusion Criteria1
- American Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events
Exclusion Criteria4
- Patients with known hypersensitivity to dexmedetomidine and Lignocaine.
- Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).
- Pregnant or lactating women.
- Patients with a history of airway anomalies or difficult intubation.
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Interventions
0.5 Mcg/kg of Dexmedetomidine will be given 10 minutes before laryngoscopy
Patients will be given 1.5 mg/kg of Lignocaine 3 minutes before laryngoscopy
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07611890