RecruitingNot ApplicableNCT07614555

Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery

Comparison of Flow-Controlled and Volume-Controlled Ventilation During Lumbar Disc Herniation Surgery: A Prospective Randomized Trial

Sponsor

Ankara Etlik City Hospital

Enrollment

80 participants

Start Date

May 28, 2026

Study Type

INTERVENTIONAL

Conditions

Mechanical Ventilation Lumbar Disc Herniation Surgery

Summary

This prospective randomized trial aims to compare the effects of flow-controlled ventilation (FCV) and volume-controlled ventilation (VCV) on intraoperative airway pressures and oxygenation in patients undergoing lumbar disc herniation surgery under general anesthesia. Adult patients aged 18-65 years, with ASA physical status I-III and a body mass index of 18-30 kg/m², will be allocated to receive either FCV or VCV during routine intraoperative mechanical ventilation. Ventilatory parameters, including peak airway pressure, plateau pressure, pulmonary compliance, EtCO₂, SpO₂, and arterial blood gas variables, will be recorded at predefined time points after intubation. The primary endpoint is the PaO₂ value measured after 20 minutes in the prone position. By comparing respiratory mechanics and oxygenation between the two ventilation modes, this study aims to contribute to the optimization of intraoperative ventilatory management in lumbar disc herniation surgery.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Inclusion Criteria3

Age between 18 and 65 years
ASA physical status I-III
Body Mass Index between 18 and 30 kg/m²

Exclusion Criteria7

Age < 18 years or > 65 years
Known or previously diagnosed pulmonary disease
Patients with severe preoperative pulmonary function impairment (e.g., FEV₁ < 50% predicted, severe restrictive or obstructive pathology)
Patients with markedly altered lung anatomy or function due to prior major thoracic surgery
Patients who were dependent on supplemental oxygen therapy in the preoperative period
ASA physical status IV or higher
Refusal or inability to provide informed consent

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Interventions

PROCEDUREFCV Group

Patients allocated to the FCV group will receive intraoperative mechanical ventilation using a flow-controlled ventilation mode during surgery under general anesthesia. Patients will be started on ventilation after intubation with 50% oxygen, driving pressure 12, PEEP 5, and a 1:1 inspiration/expiratory ratio.

PROCEDUREVCV Group

Patients allocated to the VCV group will receive intraoperative mechanical ventilation using a conventional volume-controlled ventilation mode throughout surgery under general anesthesia. Patients will be started on ventilation after intubation with 50% oxygen, 7 ml/ideal body weight tidal volume, PEEP 5, 12 breaths per minute frequency, and a 1:2 inspiration/expiration ratio.