RecruitingPhase 2NCT07212595

Biomarker and Renal Angina Validation to Assess Heart-Kidney Outcomes After Amino Acid Therapy


Sponsor

Dana Fuhrman

Enrollment

30 participants

Start Date

Jul 8, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of the BRAVE-HEART study is to learn if an amino acid infusion can reduce the risk of developing acute kidney injury after cardiac surgery in children. The main questions it aims to answer are: 1. Does an amino acid infusion decrease the number of participants with acute kidney injury? 2. Does an amino acid infusion decrease the number of days that participants are on a ventilator after cardiac surgery? Researchers will compare amino acids to a placebo (a look-alike substance that contains no drug) to see if amino acids decrease the number of participants with acute kidney injury. Participants will receive an amino acid or placebo infusion for up to 72 hours starting during cardiac surgery and only while in the operating room or the intensive care unit.


Eligibility

Max Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Amino Acid infusion and a drug called Lactated ringers solution for people with acute kidney injury and mechanical ventilation. The study is currently recruiting participants at 1 location.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAmino Acid infusion

Amino acid infusion of 2 grams/kilogram of participant weight/day for up to 72 hours

DRUGLactated ringers solution

Placebo infusion to match the volume of the amino acid infusion in grams/kilogram/day


Locations(1)

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

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NCT07212595


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