Genetic, Microbiological and Behavioral Factors in Obesity
OPTIMIZE GEN - Outcomes of Persistence and Treatment With tIrzepatide deterMined by Genetic, mIcrobiological & bEhavioral Factors in obEsity
Jan Kochanowski University
200 participants
May 23, 2026
OBSERVATIONAL
Conditions
Summary
This study will assess the impact of genetic markers, microbiological (microbiome) and behavioral factors on tolerance, adherence and effectiveness of dual GLP1/GIP RA in the treatment of obesity. 200 consecutive patients who meet all inclusion and none of the exclusion criteria will be enrolled.
Eligibility
Plain Language Summary
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Interventions
GLP1 RA and GIP R polymorphisms will be assesed from venous blood samples
stool samples and oral cavity swabs for gut microbiome will be collected to assess V3 and V4 of gene 16s rRNA
Locations(2)
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NCT07650149