Remodelling of the Lower Airways in Chronic Cough
Does Chronic Cough Lead to Injury and Remodelling of the Lower Airways?
Medical University of Warsaw
40 participants
Oct 1, 2022
OBSERVATIONAL
Conditions
Summary
The aim of the study is to assess if chronic cough leads to injury and remodelling of the airways. We plan to analyse bronchial injury and remodelling in patients with refractory chronic cough lasting longer than 12 month . Assessment of injury mediators will be performed in blood and bronchoalveolar lavage fluid. Remodelling features will be analysed based on chest CT scan and pathologic specimens. Injury of epithelium will be assessed in bronchial biopsy specimens. The relationship between the duration, severity of chronic cough, and bronchial inflammation, damage, remodelling will be analysed.
Eligibility
Plain Language Summary
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Interventions
Assessment of airway remodeling features on chest CT in patients with chronic cough. Evaluation of airway injury and remodeling based on biological specimens obtained from the lower airways during bronchoscopy.Bronchoscopy is performed if clinically indicated.
Locations(4)
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NCT07659860