A Phase III Study to Investigate the Efficacy and Safety of the Combination of Elecoglipron and Dapagliflozin in Adults With Type 2 Diabetes Mellitus
A Randomized, Double-blind, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron and Dapagliflozin in Combination, Compared With Elecoglipron Alone and Dapagliflozin Alone, in Adults With Type 2 Diabetes Mellitus (Eluminate-5)
AstraZeneca
2,000 participants
Jul 6, 2026
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron and dapagliflozin in combination, compared with elecoglipron alone and dapagliflozin alone, in adults with type 2 diabetes mellitus (T2DM) inadequately managed with lifestyle management alone or treated with other background glucose-lowering medication.
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Elecoglipron is administered orally once daily.
Dapagliflozin administered orally once daily.
A placebo matching elecoglipron administered orally once daily.
A placebo matching dapagliflozin administered orally once daily.
Locations(272)
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NCT07662109