RecruitingPhase 3NCT07662213

A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus

A Randomized, Open-label, Parallel-group Phase III Study to Evaluate the Efficacy, Safety, and Tolerability of Elecoglipron Compared With Oral Semaglutide in Adults With Type 2 Diabetes Mellitus (Eluminate-2)

Sponsor

AstraZeneca

Enrollment

1,200 participants

Start Date

Jul 6, 2026

Study Type

INTERVENTIONAL

Conditions

Type 2 Diabetes Mellitus

Summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Elecoglipron and a drug called Semaglutide for people with type 2 diabetes mellitus. The study is currently recruiting participants at 201 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGElecoglipron

Elecoglipron is administered orally once daily.

DRUGSemaglutide

Semaglutide is administered orally once daily.

Locations(209)

Research Site

Birmingham, Alabama, United States

Research Site

Mesa, Arizona, United States

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Phoenix, Arizona, United States

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Tempe, Arizona, United States

Research Site

Covina, California, United States

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Encinitas, California, United States

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Garden Grove, California, United States

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Loma Linda, California, United States

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Long Beach, California, United States

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Pomona, California, United States

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Sacramento, California, United States

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Bridgeport, Connecticut, United States

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Crystal River, Florida, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Lake City, Florida, United States

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Leesburg, Florida, United States

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Orlando, Florida, United States

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Lilburn, Georgia, United States

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Idaho Falls, Idaho, United States

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Melrose Park, Illinois, United States

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Evansville, Indiana, United States

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Ames, Iowa, United States

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Wichita, Kansas, United States

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Bowling Green, Kentucky, United States

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Rockville, Maryland, United States

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Southfield, Michigan, United States

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Minneapolis, Minnesota, United States

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Jefferson City, Missouri, United States

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Kansas City, Missouri, United States

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Omaha, Nebraska, United States

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Henderson, Nevada, United States

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Las Vegas, Nevada, United States

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Albuquerque, New Mexico, United States

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Durham, North Carolina, United States

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Morehead City, North Carolina, United States

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Raleigh, North Carolina, United States

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Statesville, North Carolina, United States

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Wilmington, North Carolina, United States

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Columbus, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Feasterville-Trevose, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Myrtle Beach, South Carolina, United States

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North Charleston, South Carolina, United States

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Memphis, Tennessee, United States

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Morristown, Tennessee, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Houston, Texas, United States

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Katy, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Sugar Land, Texas, United States

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Weslaco, Texas, United States

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Bountiful, Utah, United States

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Salt Lake City, Utah, United States

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Leesburg, Virginia, United States

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Norfolk, Virginia, United States

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Renton, Washington, United States

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Seattle, Washington, United States

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Seattle, Washington, United States

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Morgantown, West Virginia, United States

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Buenos Aires, Argentina

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Buenos Aires, Argentina

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Caba, Argentina

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Ciudad de Buenos Aires, Argentina

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Rosario, Argentina

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San Nicolás, Argentina

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San Vicente, Argentina

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Botany, Australia

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East Toowoomba, Australia

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Fitzroy, Australia

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Heidelberg Heights, Australia

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Kingswood, Australia

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Melbourne, Australia

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Parkville, Australia

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Penrith, Australia

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St Leonards, Australia

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Brasília, Brazil

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Campinas, Brazil

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Curitiba, Brazil

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Natal, Brazil

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Porto Alegre, Brazil

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São José dos Campos, Brazil

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São Paulo, Brazil

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Plovdiv, Bulgaria

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Sofia, Bulgaria

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Sofia, Bulgaria

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Sofia, Bulgaria

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Yambol, Bulgaria

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Vancouver, British Columbia, Canada

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Guelph, Ontario, Canada

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Sarnia, Ontario, Canada

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Scarborough Village, Ontario, Canada

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Stouffville, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Saint-Charles-Borromée, Quebec, Canada

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Changsha, China

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Changsha, China

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Hefei, China

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Hefei, China

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Huai'an, China

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Langfang, China

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Liangyugang, China

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Luoyang, China

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Nanjing, China

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Nanyang, China

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Pinggu, China

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Pingxiang, China

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Shijiazhuang, China

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Tianjin, China

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Yueyang, China

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Bad Oeynhausen, Germany

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Berlin, Germany

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Chemnitz, Germany

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Damme, Germany

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Duisburg, Germany

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Elsterwerda, Germany

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Erlangen, Germany

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Essen, Germany

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Falkensee, Germany

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Gladbeck, Germany

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Hamburg, Germany

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Hamburg, Germany

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Leipzig, Germany

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Mannheim, Germany

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Münster, Germany

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Oldenburg, Germany

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Pirna, Germany

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Sankt Ingbert, Germany

Research Site

Wangen, Germany

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Budapest, Hungary

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Budapest, Hungary

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Budapest, Hungary

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Debrecen, Hungary

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Salgótarján, Hungary

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Szeged, Hungary

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Szolnok, Hungary

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Zalaegerszeg, Hungary

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Bari, Italy

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Bologna, Italy

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Chieti, Italy

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Milan, Italy

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Milan, Italy

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Modena, Italy

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Naples, Italy

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Roma, Italy

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Roma, Italy

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Asahikawa-shi, Japan

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Chūōku, Japan

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Kamakura-shi, Japan

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Koga-shi, Japan

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Kumamoto, Japan

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Mitaka-shi, Japan

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Mito, Japan

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Miyazaki, Japan

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Nagoya, Japan

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Nagoya, Japan

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Naka, Japan

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Naka, Japan

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Nishinomiya-shi, Japan

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Osaka, Japan

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Sapporo, Japan

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Takamatsu, Japan

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Bialystok, Poland

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Krakow, Poland

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Lodz, Poland

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Lublin, Poland

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Poznan, Poland

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Radom, Poland

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Warsaw, Poland

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Warsaw, Poland

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Busan, South Korea

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Changwon-si, South Korea

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Daegu, South Korea

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Daejeon, South Korea

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Daejeon, South Korea

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Guri-si, South Korea

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Incheon, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Seoul, South Korea

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Changhua, Taiwan

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Kaohsiung City, Taiwan

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New Taipei City, Taiwan

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Taichung, Taiwan

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Taichung, Taiwan

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Taichung, Taiwan

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Tainan, Taiwan

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Taipei, Taiwan

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Taoyuan, Taiwan

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Yung Kang City, Taiwan

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Aberdeen, United Kingdom

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Addlestone, United Kingdom

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Banbury, United Kingdom

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Bristol, United Kingdom

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Bristol, United Kingdom

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Edinburgh, United Kingdom

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Hounslow, United Kingdom

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Penzance, United Kingdom

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Poole, United Kingdom

Research Site

Soham, United Kingdom

Research Site

Wansford, United Kingdom

Research Site

Yate, United Kingdom

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NCT07662213

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