Low-Dose Radiotherapy for Alzheimer's Disease
Low-Dose Radiotherapy for Alzheimer's Disease: A Phase I/II Open-Label Feasibility and Safety Study (LDRT-MIND Trial)
Evan Thomas
50 participants
Jul 15, 2026
INTERVENTIONAL
Conditions
Summary
To evaluate the safety and tolerability of low-dose whole brain radiotherapy (WBRT) delivered as an induction course of 0.3 Gy × 10 fractions (3.0 Gy total) followed by 12 months of monthly maintenance LDRT (0.3 Gy × 10 fractions; 3.0 Gy total) in patients with Alzheimer's disease or dementia with inflammatory components
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Low dose whole brain radiotherapy delivered as an induction course of 10 fractions followed by 12 months of monthly maintenance LDRT in 10 fractions starting 2 months post-induction
Locations(1)
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NCT07693140