Periodontitis on Gingival Crevicular Fluid Metobolomics
Impact of Periodontitis on Metabolomics in Gingival Crevicular Fluid
University of Catania
60 participants
May 4, 2026
OBSERVATIONAL
Conditions
Summary
This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults. Participants will undergo a periodontal examination and gingival crevicular fluid collection during a single study visit. Targeted metabolomic analysis will be used to identify differences between the two groups and associations with periodontal clinical parameters.
Eligibility
Inclusion Criteria4
- Age between 18 and 70 years.
- Ability to understand the study procedures and provide written informed consent.
- For the periodontitis group: diagnosis of periodontitis according to the 2018 classification of periodontal diseases.
- For the healthy control group: periodontal health according to the 2018 classification, with no current diagnosis or history of periodontitis.
Exclusion Criteria3
- Periodontal treatment during the previous 6 months.
- Use of antibiotics, non-steroidal anti-inflammatory drugs, or immunosuppressive agents during the previous 6 months.
- Pregnancy.
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Interventions
Periodontal probing depth measured in millimeters
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT07739732