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RecruitingNot ApplicableNCT07740447

Impact of Non-surgical Periodontal Treatment on Targeted Metabolomics

Effects of Minimally Non-surgical Periodontal Treatment Versus Quadrantwise Subgingival Instrumentations on Targeted Metabolomics in Gingival Crevicular Fluid

Sponsor

University of Catania

Enrollment

60 participants

Start Date

May 4, 2026

Study Type

INTERVENTIONAL

Conditions

Periodontitis

Summary

A double-blind randomized-controlled clinical trial is conducted in order to evaluate the impact of non-surgical periodontal treatment by means of minimally invasive approach MINST or Q-SI (quadrantwise) approach in subjects with periodontitis on targeted metabolomics in gingival crevicular fluid

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Inclusion Criteria1

  • Diagnosis of Periodontitis

Exclusion Criteria3

  • Periodontal treatment during the last 6 months
  • Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
  • Pregnancy

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Interventions

OTHERProbing depth reduction

Probing depth reduction in millimetres before and after treatment

Locations(1)

AOU Policlinico G. Rodolico

Catania, Italy, Italy

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NCT07740447

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