RecruitingPhase 3NCT07770841

Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight

Efficacy and Safety of Once Daily Oral Semaglutide in Adults With Overweight or Obesity


Sponsor

Novo Nordisk A/S

Enrollment

450 participants

Start Date

Aug 12, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to see how oral semaglutide, when taken in lower doses help lowering of body weight in participants with excess body weight when compared to 'dummy' tablets (placebo). Results from this study will help select the most optimal lower dose of oral semaglutide that can be used for treating participants living with overweight or obesity.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo and a drug called Semaglutide for people with obesity and overweight. The study is currently recruiting participants at 62 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGSemaglutide

Participants will receive semaglutide orally.

DRUGPlacebo

Participants will receive placebo orally.


Locations(62)

Uni of Alabama at Birmingham

Birmingham, Alabama, United States

Headlands Research California, LLC

Escondido, California, United States

National Research Institute - Huntington Park

Huntington Park, California, United States

Los Angeles Institute for Metabolic Research

Los Angeles, California, United States

ERG Holding Company, LLC / Evolution Research Group, LLC

Delray Beach, Florida, United States

ERG Holding Company, LLC / Evolution Research Group, LLC

Fort Myers, Florida, United States

Jedidiah Clinical Research

Tampa, Florida, United States

East West Med Res Inst

Honolulu, Hawaii, United States

L-MARC Research Center

Louisville, Kentucky, United States

StudyMetrix Research LLC

City of Saint Peters, Missouri, United States

Jubilee Clinical Research, Inc.

Las Vegas, Nevada, United States

Corvallis Clinic PC Clinical Research Department

Corvallis, Oregon, United States

UPA Ctr Weight and Eating Dis

Philadelphia, Pennsylvania, United States

Spartanburg Medical Research

Spartanburg, South Carolina, United States

Cedar Health Research

Dallas, Texas, United States

Selma Medical Associates

Winchester, Virginia, United States

Anima Research Center

Alken, Belgium

Imelda

Bonheiden, Belgium

UZ Brussel - Universitair Ziekenhuis Brussel

Brussels, Belgium

Universitair Ziekenhuis Gent

Ghent, Belgium

KORMONT

Kluisbergen, Belgium

AIPSMC - DiMed EOOD

Haskovo, Bulgaria

Medical Center Zdrave Lom EOOD

Lom, Bulgaria

IPMC - Dr. Elizabeta Dimitrova

Petrich, Bulgaria

MHAT Hadzhi Dimitar OOD

Sliven, Bulgaria

DCC Neoklinik EAD

Sofia, Bulgaria

DCC 1 Velingrad EOOD

Velingrad, Bulgaria

Aarhus Universitetshospital, Steno Diabetes Center Aarhus

Aarhus N, Denmark

Gentofte Hospital - Center for Klinisk Metabolisk Forskning

Hellerup, Denmark

Regionshospitalet Gødstrup, Hjertesygdomme

Herning, Denmark

Hôpital Privé Saint Martin_Service de chirurgie digestive

Caen, France

LES HOPITAUX DE CHARTRES_HOPITAL LOUIS PASTEUR_Service d'endocrinologie

Le Coudray, France

Hôpital Privé La Louvière_Service de chirurgie

Lille, France

CENTRE DE RECHERCHE CLINIQUE PORTES DU SUD_Service d'Endocrinologie-Diabétologie-Maladies Métaboliques

Vénissieux, France

City Hospital Kliniki Monoprosopi I.K.E.

Kalamata, Greece

Athens Medical Center S.A. (Iatriko Athinon) - Diabetes and Obesity Unit

Marousi, Greece

Athens Medical Center S.A. (Iatriko Peristeriou) - Diabetes, obesity and cardiometabolic diseases department

Peristeri, Greece

NextHealth S.A. - Department of Endocrinology, Metabolism & Diabetes

Thessaloniki, Greece

Thermi Clinic S.A. - Diabetes and Internal Medicine Department

Thessaloniki, Greece

Progress Clinical Research Amsterdam

Amsterdam, Netherlands

Praktijk Dokters van Nederhoven

Zwijndrecht, Netherlands

Progress Clinical Research Zwolle

Zwolle, Netherlands

Kresmed Sp. z o. o.

Bialystok, Poland

Athleticomed Sp. z o.o.

Bydgoszcz, Poland

Gierach-Med

Bygdoszcz, Poland

Santa Sp. z o.o.

Lodz, Poland

Centrum Zdrowia Metabolicznego Paweł Bogdański

Poznan, Poland

Velocity Nova Sp. z o.o.

Staszów, Poland

NBR Polska Tomasz Klodawski

Warsaw, Poland

Care Access Polska Sp. Z o.o.

Warsaw, Poland

FutureMeds Sp. z o.o.

Warsaw, Poland

HU de Fuenlabrada_Endocrinología

Fuenlabrada, Madrid, Spain

CPE Bola Azul_Endocrinología y Nutrición

Almería, Spain

Hosp. Vithas Sevilla_Endocrino y Nutrición

Castilleja de la Cuesta, Spain

Hospital Naval Ferrol

Ferrol, Spain

Clínica Palacios Madrid

Madrid, Spain

Clínica Gaias Santiago

Santiago de Compostela, Spain

Clínica Nuevas Tecnologías en Diabetes y Endocrinología

Seville, Spain

H. Infanta Luisa_Endocrino y Obesidad

Seville, Spain

CTC GoCo Mölndal

Mölndal, Sweden

Enheten för Kliniska Studier (EKS), Örebro

Örebro, Sweden

CTC Stockholm

Stockholm, Sweden

View Full Details on ClinicalTrials.gov

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NCT07770841


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