RecruitingNot ApplicableNCT07790718

Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer

The Effects of Exercise on Colorectal Cancer Promotion Following Pelvic Radiotherapy for Prostate Cancer


Sponsor

City of Hope Medical Center

Enrollment

30 participants

Start Date

Dec 16, 2026

Study Type

INTERVENTIONAL

Conditions

Summary

This clinical trial evaluates the effects of exercise therapy on signs of colorectal cancer in colon tissue and blood in people who completed pelvic radiation therapy for prostate cancer. People who get radiation in the pelvic area have a higher chance of developing colon cancer years later. This is because radiation can cause new mutations and inflammation. Research shows that exercise lowers colon cancer risk by about 30%. The results of this trial may help researchers better understand how exercise affects the development of colorectal cancer in patients who were treated with pelvic radiation therapy for prostate cancer.


Eligibility

Sex: MALEMin Age: 40 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying Aerobic Exercise, Biopsy Procedure, and others for people with colon polyp, colorectal carcinoma, and other related conditions. The study is currently recruiting participants at 2 locations. People eligible for this study include men aged 40 Years to 80 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERAerobic Exercise

Participate in individualized walking sessions

PROCEDUREBiopsy Procedure

Undergo biopsy

PROCEDUREBiospecimen Collection

Undergo collection of blood sample

PROCEDUREColonoscopy

Undergo SOC colonoscopy

OTHERData Collection

Undergo collection of Apple Health data

OTHERPhysical Performance Testing

Ancillary studies

OTHERQuestionnaire Administration

Ancillary studies

PROCEDURESigmoidoscopy

Undergo SOC flex sigmoidoscopy

OTHERSurvey Administration

Complete survey


Locations(2)

City of Hope Medical Center

Duarte, California, United States

City of Hope at Irvine Lennar

Irvine, California, United States

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NCT07790718


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