RecruitingNCT07806604

Real World Study of Icotinib in Adjuvant Post Surgical Treatment for Stage IA2 High Risk to IB EGFR Mutant Non Small Cell Lung Cancer

Multicenter, Retrospective, Observational Study of Icotinib for Post-Surgical Adjuvant Therapy in Stage IA2 High-Risk to IB Non-Small-Cell Lung Cancer With Positive EGFR-Sensitive Mutations


Sponsor

Betta Pharmaceuticals Co., Ltd.

Enrollment

2,572 participants

Start Date

Sep 1, 2026

Study Type

OBSERVATIONAL

Conditions

Summary

This is a multicenter, retrospective, observational real-world study designed based on real-world data. Eligible medical institutions that meet standardized data quality requirements and have an adequate sample size will be enrolled in this study. The treatment group consists of patients with completely resected (R0) stage IA2 high-risk to IB non-small cell lung cancer (NSCLC) harboring EGFR-sensitizing mutations who received adjuvant icotinib therapy after radical resection. The control group includes patients with completely resected (R0) stage IA2 high-risk to IB NSCLC with positive EGFR-sensitizing mutations who received routine observational follow-up after surgery. Propensity score-matched analyses will be conducted between the treatment and control groups to evaluate the efficacy and safety of adjuvant icotinib therapy in this patient population.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Icotinib and Routine Observational for people with nsclc (non-small cell lung cancer). The study is currently recruiting participants at 2 locations. People eligible for this study include aged 18 Years and older.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGIcotinib

Icotinib,tablets, usually 125mg per dose (1 tablet), TID, orally

OTHERRoutine Observational

Routine Observational Follow-up


Locations(2)

Beijing Cancer Hospital

Beijing, Beijing Municipality, China

Shanghai Pulmonary Hospital

Shanghai, Shanghai Municipality, China

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NCT07806604


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