Phase 1 Adults Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1
Safety and Tolerability Trial of Psilocybin in Healthy Older Adults
Healthy VolunteerOlder Adults (65-85 Years)
University of Colorado, Denver40 enrolled6 locationsNCT07516405
Recruiting
Phase 1
A Study of SYNT-101 to Test Safety, Tolerability and Pharmacodynamics of SYNT-101 in Healthy and Overweight Adults
HealthyOverweight and Obese Adults
Syntis Bio64 enrolled1 locationNCT07307274
Recruiting
Phase 1
A Study to Evaluate the Effect of Food on the Bioavailability of AJ201, and Safety, Tolerability, and Pharmacokinetics of AJ201 in Japanese and White Healthy Male Participants
Food Effect in Healthy VolunteersHealthy Male Adults
AnnJi Pharmaceutical Co., Ltd.26 enrolled1 locationNCT07549919
Recruiting
Phase 1Phase 2
A Study of HRS-6208 in Combination With HRS-8080, or Fulvestrant, or Letrozole, With or Without HRS-6209 in Patients With Advanced Unresectable or Metastatic Breast Cancer
Advanced Unresectable or Metastatic Breast Cancer of Adults
Shandong Suncadia Medicine Co., Ltd.180 enrolled2 locationsNCT07389733
Recruiting
Phase 1
A Study（Phase I）of GS3-007a Dry Suspension in Healthy Chinese Adults
Healthy Adults
Changchun GeneScience Pharmaceutical Co., Ltd.32 enrolled1 locationNCT07473570
Recruiting
Phase 1
Phase 1a Single Ascending Dose Study of MIB-725 in Healthy Adults
Healthy Adults
Metro International Biotech, LLC32 enrolled1 locationNCT06815991
Recruiting
Phase 1
Safety and Efficacy of Injectable Klotho Plasmid Gene Therapy in Humans
Healthy Adults
Minicircle24 enrolled2 locationsNCT07216781
Recruiting
Phase 1
Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders
Temporal Interference StimulationHealth AdultsSafety and Effectiveness+1 more
Taipei Veterans General Hospital, Taiwan80 enrolled1 locationNCT07179848
Recruiting
Phase 1
Study of ALV-100 to Assess Safety, Tolerability, and PK/PD in Overweight/Obese Participants With or Without T2D
Overweight or Obese AdultsOverweight or Obese, Type 2 Diabetes
Alveus Therapeutics, Inc.180 enrolled1 locationNCT07399678
Recruiting
Phase 1
A Study to Learn About How the Study Medicines Called Itraconazole and Probenecid Change How the Body Processes PF-07220060
Healthy Adults
Pfizer28 enrolled1 locationNCT07160738
Recruiting
Phase 1
A Study to Learn if Multiple Doses of the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine PF-07248144
Healthy Adults
Pfizer12 enrolled1 locationNCT07198035
Recruiting
Phase 1
A Study of EDG-15400 in Healthy Adults
Healthy Adults
Edgewise Therapeutics, Inc.108 enrolled1 locationNCT07177066
Recruiting
Phase 1
A Clinical Study of SHR-4506 Injection in Patients With Malignant Tumors
Malignant Tumors of Adults
Suzhou Suncadia Biopharmaceuticals Co., Ltd.102 enrolled2 locationsNCT07068932
Recruiting
Phase 1
Ph1, Randomized, Double-Blind and Controlled, Dose Escalation and Expansion Study to Assess the Safety and Pharmacokinetics of JST-010 in Healthy Adults
Pre-exposure Prophylaxis Against Pneumonic Plague in Healthy Adults
Just-Evotec Biologics104 enrolled1 locationNCT06943378
Recruiting
Phase 1
Tracing the Metabolic Flux of Orally Administered NAD+ Precursors
Healthy Adults
Metro International Biotech, LLC32 enrolled1 locationNCT06882096
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of betamethsone OV ointment applied to the skin in healthy male and female volunteers.
Diprosone OV ointment is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12624000621516
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of betamethsone ointment applied to the skin in healthy male and female volunteers.
Betamethasone ointment is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12624000107527
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of 9-fluoro-11ß-hydroxy- 16ß-methyl-3,20-dioxopregna- 1,4-diene-17,21-diyl dipropanoate cream applied to the skin in healthy male and female volunteers.
9-fluoro-11ß-hydroxy- 16ß-methyl-3,20-dioxopregna- 1,4-diene-17,21-diyl dipropanoate cream is indicated for the topical treatment of eczema and psoriasis in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12623001003662
Completed
Phase 1
Pivotal in vivo bioequivalence study comparing two formulations of methylprednisolone aceponate fatty ointment applied to the skin in healthy male and female volunteers.
Methylprednisolone aceponate fatty ointment is indicated for the short term (up to 7 days) treatment of the milder form of eczema, dermatitis and other steroid responsive skin conditions which do not require the use of a more active topical corticosteroid in children and adults.
Zenith Technology Corporation Limited90 enrolled1 locationACTRN12620000160932
Completed
Phase 1
Pharmacologically Targeting Sleep Spindles to Improve Cognition in Ageing
Cognitively-intact ageing cohort which includes adults with and without subjective memory complaints
Woolcock Institute of Medical Research24 enrolled1 locationACTRN12619001728123