Phase 1 Advanced Cancer Clinical Trials
42 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 42 trials
Recruiting
Phase 1
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
Metastatic CancerAdvanced CancerSolid Tumor
Jazz Pharmaceuticals332 enrolled15 locationsNCT05557045
Recruiting
Phase 1
A Study of IMC-002 in Patients With Advanced Cancer Failed to Standard Therapy
Advanced Cancer
ImmuneOncia Therapeutics Inc.62 enrolled3 locationsNCT05276310
Recruiting
Phase 1
A Study of PHN-012 in Patients With Advanced Solid Tumors
Pancreatic CancerColon CancerAdvanced Cancer+2 more
Pheon Therapeutics165 enrolled21 locationsNCT07127874
Recruiting
Phase 1Phase 2
Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC
Advanced CancerClear Cell Renal Cell Carcinoma
M.D. Anderson Cancer Center100 enrolled1 locationNCT05663710
Recruiting
Phase 1Phase 2
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
MelanomaAdvanced Solid TumorMetastasis+5 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Phase 1Phase 2
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
Breast CancerBreast Cancer MetastaticOvarian Cancer+6 more
Incyclix Bio150 enrolled18 locationsNCT05735080
Recruiting
Phase 1Phase 2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Ovarian CancerEndometrial CancerMetastatic Cancer+6 more
Artios Pharma Ltd442 enrolled79 locationsNCT04657068
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK201 in Participants With Advanced Solid Tumors
Advanced CancerAdvanced Solid Tumors
Shanghai Allink Biotherapeutics Co., Ltd.202 enrolled2 locationsNCT06656390
Recruiting
Phase 1Phase 2
A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer
Metastatic Solid TumorAdvanced Cancer
Memorial Sloan Kettering Cancer Center77 enrolled1 locationNCT05004116
Recruiting
Phase 1
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
Gastric CancerEsophageal AdenocarcinomaMetastatic Cancer+5 more
I-Mab Biopharma US Limited330 enrolled21 locationsNCT04900818
Recruiting
Phase 1
Phase 1b Trial of BMS-986504 in Combination With Olaparib in Patients With MTAP Loss
Advanced CancerSolid Tumor
M.D. Anderson Cancer Center36 enrolled1 locationNCT07382544
Recruiting
Phase 1
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Breast CancerProstate CancerMetastatic Solid Tumor+3 more
Angiex, Inc.80 enrolled6 locationsNCT06440005
Recruiting
Phase 1
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
Cervical CancerAdvanced Cancer
Institute of Cancer Research, United Kingdom61 enrolled3 locationsNCT05082259
Recruiting
Phase 1
A Study of MGC026 in Participants With Advanced Solid Tumors
Advanced Solid TumorSquamous Cell Carcinoma of Head and NeckMetastatic Cancer+1 more
MacroGenics250 enrolled12 locationsNCT06242470
Recruiting
Phase 1
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of TQB3122 Capsules in Subjects With Advanced Malignant Tumors
Advanced Cancer
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.86 enrolled5 locationsNCT07269145
Recruiting
Phase 1
Samarium Optimized for Long-lasting Analgesia in Cancerous End-stage Bone Pain
Bone PainMetastatic Bone TumorBone Metastases in Subjects With Advanced Cancer
Telix Pharmaceuticals (Innovations) Pty Limited33 enrolled3 locationsNCT07197645
Recruiting
Phase 1Phase 2
A Safety, Pharmacokinetic and Clinical Activity Study of NUC-7738 in Patients With Advanced Solid Tumours and Lymphoma
MelanomaAdvanced CancerSolid Tumor+1 more
NuCana plc135 enrolled9 locationsNCT03829254
Recruiting
Phase 1Phase 2
Mutant KRAS G12V-specific TCR Transduced T Cell Therapy for Advanced Pancreatic Cancer
Pancreatic CancerAdvanced CancerPancreatic Ductal Adenocarcinoma+1 more
Changhai Hospital30 enrolled1 locationNCT04146298
Recruiting
Phase 1
Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors
Advanced Cancer
Riboscience, LLC.164 enrolled14 locationsNCT05270213
Recruiting
Phase 1Phase 2
A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of TST001 in Advanced or Metastatic Solid Tumors
Advanced Cancer
Suzhou Transcenta Therapeutics Co., Ltd.320 enrolled40 locationsNCT04495296