Phase 1 Advanced Cancer Clinical Trials
48 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 48 trials
Recruiting
Phase 1
CT-95 in Advanced Cancers Associated With Mesothelin Expression
Colorectal, CancerMesothelin-Expressing TumorsEpithelial Ovarian Cancer+8 more
Context Therapeutics Inc.70 enrolled9 locationsNCT06756035
Recruiting
Phase 1
MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
Triple-Negative Breast CancerPancreatic CancerMelanoma+7 more
Memgen, Inc.40 enrolled2 locationsNCT05076760
Recruiting
Phase 1
A Study of PHN-012 in Patients With Advanced Solid Tumors
Pancreatic CancerColon CancerAdvanced Cancer+2 more
Pheon Therapeutics165 enrolled20 locationsNCT07127874
Recruiting
Phase 1Phase 2
A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer
Metastatic Solid TumorAdvanced Cancer
Memorial Sloan Kettering Cancer Center77 enrolled1 locationNCT05004116
Recruiting
Phase 1Phase 2
Phase 1/2 Study of UI-102 in Selected Advanced Cancers
Advanced Cancer
United Immunity, co., Ltd.140 enrolled3 locationsNCT07605962
Recruiting
Phase 1
An Open-Label Study to Evaluate PF-07994525 in Participants With Advanced Cancers
Advanced CancerAdvanced Malignancies
Pfizer120 enrolled4 locationsNCT07426757
Recruiting
Phase 1Phase 2
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK), and Antitumor Activity of ALK201 in Participants With Advanced Solid Tumors
Advanced CancerAdvanced Solid Tumors
Shanghai Allink Biotherapeutics Co., Ltd.202 enrolled38 locationsNCT06656390
Recruiting
Phase 1
Samarium Optimized for Long-lasting Analgesia in Cancerous End-stage Bone Pain
Bone PainMetastatic Bone TumorBone Metastases in Subjects With Advanced Cancer
Telix Pharmaceuticals (Innovations) Pty Limited33 enrolled6 locationsNCT07197645
Recruiting
Phase 1Phase 2
Phase 1b/2 Study of Combination 177Lu Girentuximab Plus Cabozantinib and Nivolumab in Treatment naïve Patients With Advanced Clear Cell RCC
Advanced CancerClear Cell Renal Cell Carcinoma
M.D. Anderson Cancer Center100 enrolled1 locationNCT05663710
Recruiting
Phase 1
A Study of JZP815 Oral Capsules in Adult Participants With Advanced or Metastatic Solid Tumors Harboring Mitogen Activated Protein Kinase (MAPK) Pathway Alterations to Investigate the Safety, Dosing, and Antitumor Activity of JZP815
Metastatic CancerAdvanced CancerSolid Tumor
Jazz Pharmaceuticals332 enrolled15 locationsNCT05557045
Recruiting
Phase 1
A Study of IMC-002 in Patients With Advanced Cancer Failed to Standard Therapy
Advanced Cancer
ImmuneOncia Therapeutics Inc.62 enrolled3 locationsNCT05276310
Recruiting
Phase 1
Clinical Trial of TQB2922 Injection (Subcutaneous Injection) in Patients With Advanced Cancers
Advanced cancers
Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.42 enrolled11 locationsNCT07260708
Recruiting
Phase 1Phase 2
A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy
Colorectal, CancerHepatocellular CarcinomaMelanoma+15 more
7 Hills Pharma, LLC126 enrolled5 locationsNCT06362369
Recruiting
Phase 1Phase 2
Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer
Breast CancerBreast Cancer MetastaticOvarian Cancer+6 more
Incyclix Bio150 enrolled18 locationsNCT05735080
Recruiting
Phase 1Phase 2
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Ovarian CancerEndometrial CancerMetastatic Cancer+6 more
Artios Pharma Ltd442 enrolled79 locationsNCT04657068
Recruiting
Phase 1
Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors
Gastric CancerEsophageal AdenocarcinomaMetastatic Cancer+5 more
I-Mab Biopharma US Limited330 enrolled21 locationsNCT04900818
Recruiting
Phase 1
Phase 1b Trial of BMS-986504 in Combination With Olaparib in Patients With MTAP Loss
Advanced CancerSolid Tumor
M.D. Anderson Cancer Center36 enrolled1 locationNCT07382544
Recruiting
Phase 1
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Breast CancerLiver CancerColorectal, Cancer+8 more
Angiex, Inc.80 enrolled6 locationsNCT06440005
Recruiting
Phase 1
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
Triple-Negative Breast CancerCervical CancerAdvanced Cancer
Institute of Cancer Research, United Kingdom61 enrolled3 locationsNCT05082259
Recruiting
Phase 1
A Study of MGC026 in Participants With Advanced Solid Tumors
Breast CancerColorectal, CancerGastric Cancer+19 more
MacroGenics250 enrolled12 locationsNCT06242470