Phase 1 Advanced Solid Tumours Clinical Trials
16 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–16 of 16 trials
Recruiting
Phase 1Phase 2
Phase 1/2 Study of PYX-201 in Combination With Pembrolizumab in Advanced Solid Tumors
Advanced Solid Tumours
Pyxis Oncology, Inc220 enrolled15 locationsNCT06795412
Recruiting
Phase 1
First in Human Study of AZD9592 in Solid Tumors
Advanced Solid Tumours
AstraZeneca403 enrolled50 locationsNCT05647122
Recruiting
Phase 1
A Study of EBC-129 in Advanced Solid Tumours
Advanced Solid Tumours
EDDC (Experimental Drug Development Centre), A*STAR Research Entities98 enrolled5 locationsNCT05701527
Recruiting
Phase 1
First in Human Study of SIM0610 in Solid Tumors
Advanced Solid Tumours
Jiangsu Simcere Pharmaceutical Co., Ltd.260 enrolled7 locationsNCT07348211
Recruiting
Phase 1
A Safety and Pharmacokinetics Study of RC220 Combined With Doxorubicin in Adult Participants With Solid Tumours.
Advanced Solid TumoursSolid Tumours
Race Oncology Ltd53 enrolled5 locationsNCT06815575
Recruiting
Phase 1Phase 2
A Study of LM-168 as a Single Agent or in Combination With Toripalimab in Subjects With Advanced Solid Tumours
Advanced Solid Tumours
LaNova Medicines Limited87 enrolled6 locationsNCT06868199
Recruiting
Phase 1
A Trial to Evaluate Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of BA1301 in Advanced Solid Tumors.
Advanced Solid Tumours
Shandong Boan Biotechnology Co., Ltd70 enrolled1 locationNCT06927349
Recruiting
Phase 1
Human Epidermal Growth Factor Receptor 2 (HER2) Antibody Therapy with Lutetium-177 in Patients with Advanced Solid Tumours.
Advanced Solid Tumours
Radiopharm Theranostics Ltd24 enrolled4 locationsACTRN12625000191493
Recruiting
Phase 1Phase 2
A Phase I/II Trial of UCB4594 in Participants With Advanced Cancer
Squamous Cell Carcinoma of Head and NeckAdvanced Solid Tumours
Cancer Research UK167 enrolled2 locationsNCT06380816
Recruiting
Phase 1Phase 2
A Study of RC88 Combined With Sintilimab for Advanced Solid Tumours
Advanced Solid Tumours
RemeGen Co., Ltd.82 enrolled1 locationNCT05804526
Recruiting
Phase 1
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacology, and Preliminary Efficacy of AT-0174 in Subjects with Advanced Solid Malignancies
Locally Advanced Solid Tumours
Antido Therapeutics (Australia) Pty Ltd33 enrolled5 locationsACTRN12623000956606
Terminated
Phase 1
A pilot study of Lewis-Y targeting Chimeric Antigen Receptor T-cells given in combination with Nivolumab in Lewis-Y expressing solid tumours.
LeY Expressing Advanced Solid Tumours
Peter MacCallum Cancer Centre18 enrolled1 locationACTRN12622001542785
Active
Phase 1
A study of EnGeneIC Dream Vectors (EDV's) packaged with the chemotherapy PNU-159682, given simultaneously as non-targeted EDVs carrying an immune enhancer called EDV-60mer, in participants with advanced cancer who have no curative treatment options. .
CancerAdvanced Solid Tumours
EnGeneIC Pty Limited20 enrolled2 locationsACTRN12617000037303
Completed
Phase 1
An open-label, multi-centre Phase I study of the safety and tolerability of intravenously (IV) infused PG545 in patients with advanced solid tumours
Advanced Solid Tumours
Progen Pharmaceuticals Ltd25 enrolled1 locationACTRN12614000060640
Recruiting
Phase 1
A Phase I study of 4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid (PENAO) given as a continuous intravenous infusion, to patients with advanced solid tumours
Patients with advanced solid tumours
University of NSW35 enrolled1 locationACTRN12612000908831
Completed
Phase 1
A Phase 1 Study of Epidermal Growth Factor Receptor (EGFR) Targeted, Paclitaxel Loaded EnGeneIC Delivery Vehicles (Erbitux®EDVsPac) in Patients with Advanced Solid Tumours
Advanced Solid Tumours
EnGeneIC Pty Ltd32 enrolled1 locationACTRN12609000672257