Phase 4 Advanced Clinical Trials
15 recruitingPhase 4
What is a Phase 4 trial?
Phase 4 trials, also called post-marketing studies, are conducted after a treatment has been approved and is available to the public. They monitor long-term effectiveness and safety in a broader population.
Showing 1–15 of 15 trials
Recruiting
Phase 4
Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study
Metastatic Head and Neck Squamous Cell CarcinomaMetastatic Hepatocellular CarcinomaMetastatic Lung Non-Small Cell Carcinoma+18 more
OHSU Knight Cancer Institute160 enrolled1 locationNCT07405086
Recruiting
Phase 4
Digital Monitoring of Self-reported Symptoms by Patients Treated With Cabozantinib Plus Nivolumab for Advanced Clear-cell Renal Carcinoma
Metastatic Renal Cell CarcinomaLocally AdvancedRenal Cell Carcinoma (Kidney Cancer)
Centre Francois Baclesse83 enrolled16 locationsNCT07028125
Recruiting
Phase 4
Study Aiming to Compare the Plasma Exposure of the Payload (Free-DXd) in Patients Treated by T-DXd for Locally Advanced or Metastatic Breast Cancer According to Their BMI.
Locally Advanced or Metastatic Breast Cancers
Institut Claudius Regaud210 enrolled11 locationsNCT07195344
Recruiting
Phase 4
ctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and Relatlimab
Metastatic MelanomaAdvanced Melanoma
NYU Langone Health90 enrolled1 locationNCT07504796
Recruiting
Phase 4
RWS of Tunlametinib in NRAS-Mutant Advanced Melanoma
Melanoma Advanced
Fudan University110 enrolled1 locationNCT07445022
Recruiting
Phase 4
Enfortumab Vedotin and Pembrolizumab With Cystectomy and/or Ureterectomy for Locally Advanced or Metastatic Bladder and Upper Urothelial Tract Cancer, CAST-AI Trial
Metastatic Bladder Urothelial CarcinomaStage IV Bladder Cancer AJCC v8Metastatic Renal Pelvis and Ureter Urothelial Carcinoma+4 more
Mayo Clinic75 enrolled1 locationNCT06764095
Recruiting
Phase 4
A Retrospective and Prospective Real-world Study of Molecular Typing in the Treatment of Advanced Thyroid Cancer
Advanced Thyroid Cancer Patients Who Received Target Therapy
Fudan University800 enrolled8 locationsNCT06195228
Recruiting
Phase 4
Non-selective Beta-blocker in Compensated Advanced Chronic Liver Disease
Advanced Chronic Liver DiseasePortal HypertensionHepatic Decompensation
Chinese University of Hong Kong474 enrolled1 locationNCT06449339
Recruiting
Phase 4
Safety and Modulation of Adaptive Immunity by Iscador® Qu Viscum Album Extract in Patients With Advanced, Recurrent or Metastatic Cancers Treated With Immune Checkpoint Inhibitors
Advanced Solid Tumor
University Hospital, Basel, Switzerland100 enrolled4 locationsNCT06408688
Recruiting
Phase 4
Survival Benefit of Compound Kushen Injection in the Treatment of Advanced Colorectal Cancer
Advanced Colorectal Carcinoma
Guang'anmen Hospital of China Academy of Chinese Medical Sciences320 enrolled1 locationNCT05894694
Recruiting
Phase 4
Safety and Efficacy of Pembrolizumab in Combination with Bevacizumab + CapeOX in the Neoadjuvant Treatment of RAS-mutated, BRAF Wild-type, Microsatellite-stabilized, Locally Advanced Colorectal Cancer
Locally Advanced Colorectal Cancer
yangjianjun20 enrolled1 locationNCT06550453
Recruiting
Phase 4
The Efficacy and Safety of Pyrotinib, Trastuzumab Combined With Taxanes in the Treatment of Trastuzumab-treated HER2+ Advanced Breast Cancer (ABC).
Advanced Breast CancerHER2-positive Breast Cancer
Hebei Medical University Fourth Hospital100 enrolled1 locationNCT06217185
Recruiting
Phase 4
Comprehensive Analysis of Spatial, Temporal and Molecular Patterns of Ribociclib Efficacy and Resistance in Advanced Breast Cancer Patients
Breast CancerBreast Cancer FemaleBreast Neoplasms+4 more
Institut fuer Frauengesundheit1,000 enrolled52 locationsNCT05452213
Recruiting
Phase 4
Select the Appropriate Population for Adding CDK4/6i to Neoadjuvant Endocrine Therapy
Locally Advanced Breast CancerHormone Receptor Positive，HER2-negative Breast Cancer
Yongsheng Wang100 enrolled1 locationNCT05809024
Not Yet Recruiting
Phase 3Phase 4
A Single Patient Multiple Cross-Over Study To Determine The Efficacy Of Paracetamol In Relieving Pain Suffered By Patients With Advanced Cancer Taking Regular Opioids.
Advanced Stage Cancer Patients
The University of Queensland40 enrolled1 locationACTRN12610000893000