Phase 1 AMI Clinical Trials
56 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 56 trials
Recruiting
Phase 1
Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency
Inherited Bone Marrow Failure SyndromeFamilial Platelet Disorder With Predisposition to Myeloid Malignancies
National Cancer Institute (NCI)75 enrolled1 locationNCT06090669
Recruiting
Phase 1Phase 2
Effects of Dexmedetomidine Versus Ketamine on Inflammatory Response and Hemodynamic in Patients
Haemodynamic Rebound
New Valley University2 enrolled1 locationNCT06490731
Recruiting
Phase 1
A Study of SGT-501 Gene Therapy in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
Catecholaminergic Polymorphic Ventricular Tachycardia
Solid Biosciences Inc.18 enrolled5 locationsNCT07148089
Recruiting
Phase 1Phase 2
Evaluate REC-4881 in Participants With Familial Adenomatous Polyposis (FAP)
Familial Adenomatous Polyposis
Recursion Pharmaceuticals Inc.67 enrolled17 locationsNCT05552755
Recruiting
Phase 1
Testing for Safety and Colorectal Cancer Preventive Effects of ONC201
Colorectal CarcinomaFamilial Adenomatous PolyposisColorectal Adenomatous Polyp+1 more
National Cancer Institute (NCI)36 enrolled5 locationsNCT05630794
Recruiting
Phase 1Phase 2
Influence of Personalized Lung Volume Optimization Maneuver on Lung Function and Cardiac Performance in Children
Mechanical VentilationCongenital Heart DiseaseChildren+8 more
Charite University, Berlin, Germany80 enrolled1 locationNCT07193719
Recruiting
Phase 1Phase 2
Gene Therapy for Adenosine Deaminase Severe Combined Immune Deficiency Using Peripheral Blood and EFS ADA Vector
Adenosine Deaminase Severe Combined Immune Deficiency
University of California, Los Angeles20 enrolled1 locationNCT05432310
Recruiting
Phase 1
A Study of VERVE-102 in Patients With Familial Hypercholesterolemia or Premature Coronary Artery Disease
Premature Coronary Heart DiseaseHeterozygous Familial Hypercholesterolemia
Verve Therapeutics, Inc.85 enrolled22 locationsNCT06164730
Recruiting
Phase 1
The ENERGY Study: Evaluation of Safety and Tolerability of INZ-701 in Infants With ENPP1 Deficiency or ABCC6 Deficiency
Pseudoxanthoma ElasticumEctonucleotide Pyrophosphatase/phosphodiesterase1 DeficiencyAutosomal Recessive Hypophosphatemic Rickets+2 more
Inozyme Pharma16 enrolled7 locationsNCT05734196
Recruiting
Phase 1
A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory Dyslipidemias
HypercholesterolaemiaMetabolic DiseaseDyslipidemias+7 more
CRISPR Therapeutics AG90 enrolled18 locationsNCT07491172
Recruiting
Phase 1
Nucleoside Therapy in Patients With Telomere Biology Disorders
Dyskeratosis CongenitaTelomere Biology DisordersHoyeraal-Hreidarsson Syndrome+4 more
Suneet Agarwal36 enrolled1 locationNCT06817590
Recruiting
Phase 1
Acute Effects of Intravenous 5-MeO-DMT in Healthy Participants
5-methoxy-dimethyltryptamine (5-MeO-DMT)
University Hospital, Basel, Switzerland40 enrolled1 locationNCT07444788
Recruiting
Phase 1
A Study of Avutometinib for People With Solid Tumor Cancers
Solid TumorSolid Tumor, AdultNeuroblastoma+12 more
Memorial Sloan Kettering Cancer Center23 enrolled2 locationsNCT06104488
Recruiting
Phase 1
Acute Effects of Oral Nicotine Pouches
Nicotine Pouch Self-AdministrationNicotine Pharmacokinetic StudyNicotine Pharmacodynamic Study
Johns Hopkins University120 enrolled1 locationNCT07128329
Recruiting
Phase 1
Protocol Title: Safety and Feasibility of Autologous CD34+ Hematopoietic Stem Cells Mobilization and Apheresis in Participants With RUNX1 Familial Platelet Disorder
RUNX1 Familial Platelet Disorder
M.D. Anderson Cancer Center4 enrolled1 locationNCT06414889
Recruiting
Phase 1Phase 2
A Study of RM-718 in Healthy Subjects and Patients With MC4R Pathway Impairment
Prader-Willi SyndromeHypothalamic ObesityPWS
Rhythm Pharmaceuticals, Inc.150 enrolled7 locationsNCT06239116
Recruiting
Phase 1Phase 2
Psilocybin-Enhanced Psychotherapy for Methamphetamine Use Disorder
Amphetamine-Related Disorders
Portland VA Research Foundation, Inc30 enrolled1 locationNCT04982796
Recruiting
Phase 1
Study of BB-025, Alone and After BB-031, in Healthy Volunteers
Healthy VolunteersPharmacokineticsPharmacodynamics
Basking Biosciences, Inc.72 enrolled1 locationNCT07202663
Recruiting
Phase 1
High - Dose Vitamin C Infusion Regimen Based on Pharmacokinetic Characteristics for Patients With Advanced Malignant Solid Tumors
Vitamin C
Zhongnan Hospital18 enrolled1 locationNCT07121036
Recruiting
Phase 1
Safety Evaluation of Gene Therapy Drug in the Treatment of Primary Hypertriglyceridemic Patients With Recurrent Pancreatitis
Hypertriglyceridemia, Familial
GeneCradle Inc7 enrolled1 locationNCT05860569