Phase 1 AML Clinical Trials
75 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 75 trials
Recruiting
Phase 1
BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia
Gastric CancerAdvanced Solid TumorTNBC - Triple-Negative Breast Cancer+1 more
SillaJen, Inc.260 enrolled17 locationsNCT05768932
Recruiting
Phase 1
Study of Orally Administered AG-120 in Subjects With Advanced Hematologic Malignancies With an IDH1 Mutation
Myelodysplastic SyndromesRelapsed or Refractory Acute Myeloid Leukemia (AML)Untreated AML+1 more
Institut de Recherches Internationales Servier291 enrolled30 locationsNCT02074839
Recruiting
Phase 1Phase 2
Phase I/II Study of CAR.70- Engineered IL15-transduced Cord Blood-derived NK Cells in Conjunction With Lymphodepleting Chemotherapy for the Management of Relapse/Refractory Hematological Malignances
Hodgkin LymphomaMultiple MyelomaAcute Myeloid Leukemia (AML)+7 more
M.D. Anderson Cancer Center80 enrolled1 locationNCT05092451
Recruiting
Phase 1
A Study of Rebecsinib for Patients With Relapsed/Refractory Secondary Acute Myeloid Leukemia or High Risk Myelofibrosis
MyelofibrosisSecondary AML
Aspera Biomedicines, Inc.28 enrolled1 locationNCT07250646
Recruiting
Phase 1
First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (HR-MDS)
Acute Myeloid LeukemiaR/R AMLR/R HR-MDS+1 more
Genmab78 enrolled9 locationsNCT07384715
Recruiting
Phase 1
A Study to Investigate APL-4098 Alone and in Combination in Adults With AML or MDS
Acute Myeloid Leukemia (AML)Acute Myeloid Leukemia, in RelapseMyelodysplastic Syndrome With Excess Blasts+2 more
Apollo Therapeutics Ltd100 enrolled9 locationsNCT06372717
Recruiting
Phase 1Phase 2
Phase1b/2 Trial Of AZA + APG1252 In Patients With High-Risk AML
AML
M.D. Anderson Cancer Center52 enrolled1 locationNCT07508982
Recruiting
Phase 1
Allogeneic CAR-T(CT0890B) in NKG2DL+ R/R AML
AMLRefractory/Relapse Acute Myeloid Leukemia
Peking University People's Hospital27 enrolled1 locationNCT07617285
Recruiting
Phase 1
CART123 Cells With or Without Ruxolitinib in Relapsed/Refractory Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML)
Stephan Grupp MD PhD30 enrolled1 locationNCT07464951
Recruiting
Phase 1
CD123-Directed T-Cell Therapy for Acute Myelogenous Leukemia (CATCHAML)
B-ALLAML/MDST-ALL+1 more
St. Jude Children's Research Hospital108 enrolled2 locationsNCT04318678
Recruiting
Phase 1Phase 2
Adapt NK for High Risk Myeloid Diseases as Bridge to Allo HSCT
Acute Myelogenous LeukemiaRefractory AMLRelapsed Adult AML
Masonic Cancer Center, University of Minnesota18 enrolled1 locationNCT07591649
Recruiting
Phase 1Phase 2
The Efficacy of Triple Regimen in Newly Diagnosed AML Patients With FLT3 Mutation
AMLFLT3 Gene Mutation
Institute of Hematology & Blood Diseases Hospital, China66 enrolled1 locationNCT06561880
Recruiting
Phase 1Phase 2
Venetoclax in Combination With Ivosidenib and Azacitidine for Newly Diagnosed IDH1-Mutated AML
TreatmentAMLIDH1 Mutation
Institute of Hematology & Blood Diseases Hospital, China23 enrolled1 locationNCT06611839
Recruiting
Phase 1Phase 2
Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML
Acute Myeloid LeukemiaAMLAML, Childhood+1 more
Washington University School of Medicine68 enrolled1 locationNCT06158828
Recruiting
Phase 1
Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute Myeloid Leukemia (AML) Patients With NPM1 Mutation
AML, Adult RecurrentAML (Acute Myeloid Leukemia)AML With Mutated NPM1
BlueSphere Bio, Inc19 enrolled1 locationNCT07566585
Recruiting
Phase 1
Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia
Acute Myeloid LeukemiaAcute LeukemiaAML+9 more
Kura Oncology, Inc.171 enrolled45 locationsNCT06001788
Recruiting
Phase 1Phase 2
Proton-Based Total Marrow Irradiation for Allogeneic Transplantation in High-Risk AML/MDS
Proton TherapyAcute Myeloid Leukemia (AML)Myelodysplastic Neoplasm+2 more
Institute of Hematology and Blood Transfusion, Czech Republic16 enrolled2 locationsNCT07532824
Recruiting
Phase 1
UAB 2419-CD34 Selection Using the Automated CliniMACS Prodigy
AMLMyelodysplastic SyndromesCML+3 more
University of Alabama at Birmingham50 enrolled1 locationNCT06047886
Recruiting
Phase 1
A Study of TSC-100 and TSC-101 in AML, ALL and MDS in Patients Undergoing Allogeneic Peripheral Blood Stem Transplantation
AMLMyelodysplastic SyndromesALL, Adult
TScan Therapeutics, Inc.75 enrolled15 locationsNCT05473910
Recruiting
Phase 1
A Study of Gilteritinib in Combination With Ivosidenib or Enasidenib in People With Acute Myeloid Leukemia (AML)
Acute Myeloid Leukemia (AML)
Memorial Sloan Kettering Cancer Center18 enrolled7 locationsNCT05756777