Phase 1 Anemia Clinical Trials
24 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 24 trials
Recruiting
Phase 1Phase 2
Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia
Myelodysplastic SyndromesMyelofibrosisAnemia+4 more
Disc Medicine, Inc150 enrolled24 locationsNCT05320198
Recruiting
Phase 1Phase 2
JAK1/2 Inhibitor Ruxolitinib for Relapsed/Refractory Immune Bone Marrow Failure
Severe Aplastic AnemiaSingle Lineage Cytopenias, T-LGLHypoplastic MDS
National Heart, Lung, and Blood Institute (NHLBI)145 enrolled1 locationNCT05998408
Recruiting
Phase 1
Assessing the Safety, Tolerability, and Efficacy of APR-2020 in Pediatric and Adolescent Subjects With RPS19 Deficient Diamond-Blackfan Anemia
RPS19 Deficient Diamond-Blackfan Anemia
Apriligen, Inc.4 enrolled2 locationsNCT07476183
Recruiting
Phase 1
A Study to Evaluate the Safety, Pharmacokinetics and Preliminary Efficacy of APG-5918.
Anemia
Ascentage Pharma Group Inc.105 enrolled2 locationsNCT05773586
Recruiting
Phase 1Phase 2
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome
Myelodysplastic Syndrome (MDS)Severe Aplastic AnemiaHypo-Plastic MDS
National Heart, Lung, and Blood Institute (NHLBI)37 enrolled1 locationNCT03173937
Recruiting
Phase 1Phase 2
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Healthy VolunteersAnemia, Sickle Cell
Bristol-Myers Squibb184 enrolled19 locationsNCT06481306
Recruiting
Phase 1Phase 2
Zoledronic Acid Treatment in Patients With Congenital Dyserythropoietic Anemia
Congenital Dyserythropoietic Anemia (CDA)
Institute of Hematology & Blood Diseases Hospital, China2 enrolled1 locationNCT07471516
Recruiting
Phase 1
Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease
Sickle Cell DiseaseHb-SS DiseaseHemoglobin S+3 more
National Heart, Lung, and Blood Institute (NHLBI)25 enrolled1 locationNCT05904093
Recruiting
Phase 1Phase 2
Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone Marrow
MyelofibrosisMyelofibrosis; Anemia
University of California, Irvine10 enrolled1 locationNCT07281781
Recruiting
Phase 1
Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Severe β-Hemoglobinopathies
Beta-ThalassemiaSickle Cell DiseaseSickle Cell Anemia (HbSS, or HbSβ-thalassemia0)+1 more
Daniel Bauer10 enrolled1 locationNCT06647979
Recruiting
Phase 1Phase 2
Depleted Donor Stem Cell Transplant in Children and Adults With Fanconi Anemia After Being Conditioned With a Regimen Containing Briquilimab
Fanconi Anemia
Porteus, Matthew, MD18 enrolled1 locationNCT04784052
Recruiting
Phase 1
Autologous CD19/BCMA Dual-Target CAR-T for Relapsed/Refractory Autoimmune Diseases
Relapsed/Refractory Systemic Lupus ErythematosusRelapsed/Refractory Systemic SclerosisRelapsed/Refractory Idiopathic Inflammatory Myopathies+3 more
Beijing Boren Hospital12 enrolled1 locationNCT07361094
Recruiting
Phase 1Phase 2
A Safety, Efficacy, and Pharmacokinetic (PK) Study of HBI-002, an Oral Carbon Monoxide (CO) Therapeutic, in Subjects With Sickle Cell Disease (SCD)
Anemia, Sickle Cell
Hillhurst Biopharmaceuticals, Inc.9 enrolled2 locationsNCT06144749
Recruiting
Phase 1
A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia
Recurrent Severe Aplastic AnemiaRefractory Severe Aplastic Anemia
City of Hope Medical Center6 enrolled1 locationNCT05757310
Recruiting
Phase 1Phase 2
A Study of CM336 in Patients With Relapsed or Refractory Autoimmune Cytopenia
Autoimmune Hemolytic AnemiaEvans SyndromeAutoimmune Cytopenia+1 more
Keymed Biosciences Co.Ltd158 enrolled3 locationsNCT07175493
Recruiting
Phase 1
OM336 in Autoimmune Cytopenias
ITP - Immune ThrombocytopeniaAIHA - Warm Autoimmune Hemolytic AnemiaAIHA - Cold Autoimmune Hemolytic Anemia
Ouro Medicines32 enrolled3 locationsNCT07083960
Recruiting
Phase 1Phase 2
T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
Sickle Cell Anemia
Paul Szabolcs5 enrolled1 locationNCT03653338
Recruiting
Phase 1
CD7 CAR T Cells (RD13-02) in the Treatment of Relapsed/Refractory Severe Aplastic Anemia
RelapseRefractorySevere Aplastic Anemia
Institute of Hematology & Blood Diseases Hospital, China15 enrolled1 locationNCT06622694
Recruiting
Phase 1Phase 2
Roxadustat's Effect on Heart, Nutrition, and Inflammation in Hemodialysis Patients
Cardiovascular Diseases (CVD)Kidney Failure, ChronicMalnutrition-Inflammation Syndrome+1 more
Mansoura University46 enrolled1 locationNCT06903559
Recruiting
Phase 1
UCMSC-Exo for Chemotherapy-induced Myelosuppression in Acute Myeloid Leukemia
Acute Myeloid LeukemiaThrombocytopeniaNeutropenia+3 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology9 enrolled1 locationNCT06245746