Atrial Appendage Clinical Trials

17 recruitingLast updated: June 10, 2026

There are 17 actively recruiting atrial appendage clinical trials across 15 countries. Studies span Not Applicable, Phase 4. Top locations include Aarhus, Denmark, Aarhus, Region Midt, Denmark, Amsterdam, North Holland, Netherlands. Updated daily from ClinicalTrials.gov.


Atrial Appendage Trials at a Glance

17 actively recruiting trials for atrial appendage are listed on ClinicalTrialsFinder across 6 cities in 15 countries. The largest study group is Not Applicable with 9 trials, with the heaviest enrollment activity in Aarhus, Aarhus, and Amsterdam. Lead sponsors running atrial appendage studies include Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), AuriGen Medical Ltd, and Abbott Medical Devices.

Browse atrial appendage trials by phase

Treatments under study

About Atrial Appendage Clinical Trials

Looking for clinical trials for Atrial Appendage? There are currently 1 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Atrial Appendage trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Atrial Appendage clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 117 of 17 trials

Recruiting
Not Applicable

Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation

StrokeFrailtyAtrial Fibrillation (AF)+4 more
Guangdong Provincial People's Hospital200 enrolled1 locationNCT07441382
Recruiting
Not Applicable

Agilis RF TSP Early Feasibility Study

Left Atrial Appendage ClosureCardiac Arrythmias
Abbott Medical Devices60 enrolled3 locationsNCT07361445
Recruiting

WATCHMAN FLX Pro European Registry

Left Atrial Appendage ClosureNon-valvular Atrial Fibrillation (AF)
Boston Scientific Corporation1,000 enrolled13 locationsNCT07262255
Recruiting

CLOT-LESS - CLOsure Tailored: LEss Antithrombotic Strategy After LAAC for Stroke Prevention

Atrial FibrillationThromboembolismLeft Atrial Appendage Closure+4 more
National Medical Research Center for Therapy and Preventive Medicine464 enrolled1 locationNCT07575867
Recruiting
Not Applicable

Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion

Left Atrial Appendage Closure
Baylor Research Institute444 enrolled1 locationNCT06348394
Recruiting

Frailty in Patient Undergoing Percutaneous Left Atrial Appendage Closure.

FrailtyTranscatheter Left Atrial Appendage Closure
Josep Rodes-Cabau500 enrolled1 locationNCT05257954
Recruiting
Not Applicable

Left Atrial Appendage Closure With Versus Without Pulsed Field Ablation in Atrial Fibrillation Patients With Mild Symptoms and High Stroke Risk

ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATIONPFA Ablation and LAAC Procedures
Sir Run Run Shaw Hospital50 enrolled1 locationNCT07453940
Recruiting
Not Applicable

Atrial Fibrillation TRIal of Left Atrial Appendage Closure Using Seralene Hemostatic Suture

Atrial Fibrillation (AF)Stroke (in Patients With Atrial Fibrillation)ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION+2 more
Institute of Cardiovascular Diseases, Vojvodina200 enrolled1 locationNCT07360899
Recruiting
Not Applicable

Intracardiac Echocardiography Guided Watchman Device Implant

Atrial FibrillationLeft Atrial Appendage Thrombosis
The Cleveland Clinic100 enrolled1 locationNCT06007872
Recruiting
Phase 4

Non-antithrombotic Versus. Single Antiplatelet Therapy Following Left Atrial Appendage Closure

Left Atrial Appendage ClosureAspirinNonvalvular Atrial Fibrillation+2 more
OCEAN-SHD Study Group500 enrolled21 locationsNCT07125417
Recruiting
Not Applicable

Oral Anticoagulation Versus Left Atrial Appendage Occlusion Added to Direct Oral Anticoagulation in Patients with Stroke Despite Oral

Left Atrial Appendage Closure
Hospital Clinic of Barcelona380 enrolled1 locationNCT06869811
Recruiting

Detecting Cardiac Thrombi in Acute Ischemic Stroke on Cardiac CT Versus Transoesophageal Echocardiography

Ischemic StrokeCardioembolic StrokeLeft Atrial Appendage Thrombosis+2 more
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)39 enrolled1 locationNCT06585228
Recruiting

Austrian Left Atrial Appendage Closure Registry

Atrial FibrillationLeft Atrial Appendage Closure
Medical University of Graz200 enrolled1 locationNCT03409159
Recruiting
Not Applicable

Zenith LAA Occlusion System

Atrial FibrillationStrokeLeft Atrial Appendage
AuriGen Medical Ltd10 enrolled3 locationsNCT05951101
Recruiting
Phase 4

Can Patients With Atrial Fibrillation Safely Discontinue Anticoagulant Therapy After Cardiac Surgery? (ATLAAC)

Atrial FibrillationAnticoagulant Adverse ReactionLeft Atrial Appendage Absent
Odense University Hospital1,220 enrolled6 locationsNCT06401616
Recruiting
Not Applicable

LAmbre Versus AMPLATZER Amulet Left AtrIal Appendage Occluder for StRoke ProphylaxIs

Left Atrial Appendage Occlusion
Deutsches Herzzentrum Muenchen226 enrolled1 locationNCT06060912
Recruiting

Coherex WaveCrest Left Atrial Appendage Occlusion Study A multi-center study to evaluate the safety and efficacy of the Coherex WaveCrest Left Atrial Appendage Occlusion System

Non-valvular atrial fibrillation in anticoagulation indicated and contraindicated patient and the effect of implantation of a left atrial appendage closure system.
Coherex Medical Inc.200 enrolled4 locationsACTRN12610000921088