Phase 1 Autoimmune Clinical Trials
35 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 35 trials
Recruiting
Phase 1
A Study to Assess the Safety and Clinical Activity of Azer-cel in Participants With B-cell Mediated Autoimmune Disorders
B-cell Mediated Autoimmune Disorders
TG Therapeutics, Inc.100 enrolled8 locationsNCT06680037
Recruiting
Phase 1
Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO
Malignant Solid NeoplasmHematopoietic and Lymphoid Cell NeoplasmRheumatoid Arthritis+11 more
National Cancer Institute (NCI)300 enrolled52 locationsNCT03816345
Recruiting
Phase 1Phase 2
Controlling Hyperactive Immunity With Long-lived Lymphocytes
Rheumatoid Arthritis (RA)Autoimmune Rheumatologic DiseaseDiffuse Cutaneous Systemic Sclerosis+1 more
Quell Therapeutics Limited16 enrolled6 locationsNCT07473154
Recruiting
Phase 1
Safety and Pharmacodynamics of QH103 Cell Injection in the Treatment of Patients With Relapsed/Refractory Antibody-Mediated Neurological Autoimmune Diseases.
Neuromyelitis Optica Spectrum Disorder (NMOSD)Multiple Sclerosis (MS)Myasthenia Gravis (MG)+4 more
Tongji Hospital6 enrolled1 locationNCT07526493
Recruiting
Phase 1
A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune Diseases
Refractory Autoimmune Diseases
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company125 enrolled28 locationsNCT07115745
Recruiting
Phase 1
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single- and Multiple-Ascending Doses and Food Effect of BGB-45035 in Healthy Participants and in Adults With Autoimmune Dermatological Diseases
healthy adult participantsHealthy ParticipantsHealthy Volunteers+4 more
BeiGene211 enrolled13 locationsNCT06342713
Recruiting
Phase 1Phase 2
Autoimmune Disease Treatment With Mesenchymal Stem Cells (MSCs) and CAR-T Cells
Autoimmune Diseases
Shenzhen Geno-Immune Medical Institute30 enrolled1 locationNCT06435897
Recruiting
Phase 1Phase 2
Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders
Systemic Lupus ErythematosusLupusAutoimmune Disorders+2 more
M.D. Anderson Cancer Center47 enrolled2 locationsNCT06434363
Recruiting
Phase 1Phase 2
Daratumumab in Primary Antiphospholipid Syndrome
Autoimmune Disorders
National Institute of Allergy and Infectious Diseases (NIAID)22 enrolled8 locationsNCT05671757
Recruiting
Phase 1
A Study of Safety, Tolerability, PK, and PD of Subcutaneous GenSci136 in Healthy Adults.
Autoimmune Disease
Changchun GeneScience Pharmaceutical Co., Ltd.48 enrolled1 locationNCT07366866
Recruiting
Phase 1Phase 2
Anti-CD19 Chimeric Antigen Receptor T Cells for Refractory Autoimmune Diseases
Autoimmune Diseases
Beijing GoBroad Hospital18 enrolled1 locationNCT06688799
Recruiting
Phase 1Phase 2
A Study to Investigate Safety and Effectiveness of Porcine Pancreatic Cells (OPF-310) in Patients With Type 1 Diabetes Mellitus
Metabolic DiseaseDiabetes Mellitus, Type 1Type 1 Diabetes+14 more
Otsuka Pharmaceutical Factory, Inc.13 enrolled1 locationNCT06575426
Recruiting
Phase 1
A Phase 1 Study of Anitocabtagene Autoleucel for the Treatment of Subjects With Non-oncology Plasma Cell-related Diseases
Myasthenia GravisMuscle WeaknessAutoimmune Diseases+4 more
Arcellx, Inc.30 enrolled13 locationsNCT06626919
Recruiting
Phase 1Phase 2
Clinical Application of Al18F-NOTA-FAPI-04 PET/CT or PET/MRI Imaging in Malignant Tumor,Cardiovascular or Immune Disease
Malignant TumorHyperthyroidism, AutoimmuneCardiovascular Abnormalities
Peking Union Medical College Hospital600 enrolled1 locationNCT07400224
Recruiting
Phase 1
CAR T-cell Therapy Targeting CD19 and BCMA in Patients With B Cell Mediated Autoimmune Disease
IgA Nephropathy (IgAN)Autoimmune DiseasesSystemic Sclerosis (SSc)+3 more
The Children's Hospital of Zhejiang University School of Medicine15 enrolled1 locationNCT07305116
Not Yet Recruiting
Phase 1
A Drug-drug Interaction Study of JNJ-90858638 in Healthy Participants (Part 3 and 4: Drug-drug Interaction)
Autoimmune Disease
Janssen Research & Development, LLC40 enrolled1 locationACTRN12626000105347
Recruiting
Phase 1
Autologous CD19/BCMA Dual-Target CAR-T for Relapsed/Refractory Autoimmune Diseases
Relapsed/Refractory Systemic Lupus ErythematosusRelapsed/Refractory Systemic SclerosisRelapsed/Refractory Idiopathic Inflammatory Myopathies+3 more
Beijing Boren Hospital12 enrolled1 locationNCT07361094
Not Yet Recruiting
Phase 1
A Single and Multiple Ascending Dose Study of JNJ-90858638 in Healthy Participants (Part 1 and 2: Single and Multiple Ascending Dose)
Autoimmune Diseases
Janssen Research & Development, LLC120 enrolled1 locationACTRN12625001434482
Recruiting
Phase 1Phase 2
A Study of CM336 in Patients With Relapsed or Refractory Autoimmune Cytopenia
Autoimmune Hemolytic AnemiaEvans SyndromeAutoimmune Cytopenia+1 more
Keymed Biosciences Co.Ltd158 enrolled3 locationsNCT07175493
Recruiting
Phase 1
A Study of LUCAR-G79 in Subjects With Relapsed/Refractory Autoimmune Diseases
Relapsed/Refractory Autoimmune Diseases
Nanjing Legend Biotech Co.42 enrolled6 locationsNCT07049081