Phase 1 Brain Metastases Clinical Trials
22 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–20 of 22 trials
Recruiting
Phase 1
Assess Use of 18F-Fluciclovine for Patients With Large Brain Metastases Treated With Staged Stereotactic Radiosurgery
Brain Metastases, AdultBrain MetastasesBrain Cancer
Baptist Health South Florida20 enrolled1 locationNCT04689048
Recruiting
Phase 1
A Phase 1/1b Study of IAM1363 in HER2 Cancers
HER2-positive Breast CancerHER2 + Breast CancerHER2 Mutation-Related Tumors+10 more
Iambic Therapeutics, Inc383 enrolled48 locationsNCT06253871
Recruiting
Phase 1Phase 2
Delayed or Upfront Brain RAdiotherapy in Treatment naïve Lung Cancer Patients With Asymptomatic or Minimally Symptomatic Brain Metastases and ALK rEarrangements
Lung CancerNSCLCBrain Metastases
Joshua Palmer56 enrolled3 locationsNCT05987644
Recruiting
Phase 1Phase 2
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Metastatic Breast CancerBrain Metastases
Weill Medical College of Cornell University41 enrolled3 locationsNCT03449238
Recruiting
Phase 1Phase 2
Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases
CancerMetastatic CancerMetastasis+2 more
Baptist Health South Florida46 enrolled1 locationNCT05789589
Recruiting
Phase 1Phase 2
Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
Cervical CancerBrain Metastases, AdultDiffuse Astrocytoma, IDH-Mutant+1 more
Neonc Technologies, Inc.134 enrolled6 locationsNCT06047379
Recruiting
Phase 1
Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer
Lung CancerBrain MetastasesLung Cancer Metastatic
University of California, Davis20 enrolled1 locationNCT05452005
Recruiting
Phase 1Phase 2
Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases
Brain MetastasesHR+ Metastatic Breast Cancer
H. Lee Moffitt Cancer Center and Research Institute31 enrolled2 locationsNCT04923542
Recruiting
Phase 1
Role of Hyperpolarized 13C-Pyruvate MR Spectroscopy in Patients With Intracranial Metastasis Treated With (SRS)
Brain Metastases
Sunnybrook Health Sciences Centre276 enrolled1 locationNCT03324360
Recruiting
Phase 1
Study to Assess Safety, Tolerability and Activity of DSB2455 in Participants With Advanced Malignancies
Advanced Malignancies With Homologous Recombination Deficiency (HRD) (Breast, Ovarian, mCRPC, Brain Metastases)
Duke Street Bio Ltd90 enrolled13 locationsNCT06458712
Recruiting
Phase 1Phase 2
Study of Stereotactic Radiosurgery With Olaparib Followed by Durvalumab and Physician's Choice Systemic Therapy in Subjects With Breast Cancer Brain Metastases
Breast CancerBrain Metastases, Adult
Colette Shen41 enrolled7 locationsNCT04711824
Recruiting
Phase 1Phase 2
Defactinib and Avutometinib, With or Without Encorafenib, for the Treatment of Patients With Brain Metastases From Cutaneous Melanoma
Cutaneous MelanomaBrain Metastases
University of Utah33 enrolled2 locationsNCT06194929
Recruiting
Phase 1
Personalized Radiotherapy for Individualized Treatment Strategies and Monitoring (PRISM)
Solid Tumor, AdultBrain MetastasesSmall Cell Lung Cancer Extensive Stage
University of Texas Southwestern Medical Center45 enrolled1 locationNCT07139990
Recruiting
Phase 1
A First-In-Human, Phase 1 Study Evaluating Oral TACC3 PPI Inhibitor, AO-252, in Advanced Solid Tumors With or Without Brain Metastases
Brain Metastases From Solid TumorsSolid Tumor Malignancies
A2A Pharmaceuticals Inc.86 enrolled5 locationsNCT06136884
Recruiting
Phase 1
Phase I Study of Fractionated Stereotactic Radiation Therapy
Brain Metastases
Albert Einstein College of Medicine43 enrolled1 locationNCT03726359
Recruiting
Phase 1
18F-Fluciclovine PET Amino Acid Evaluation of Brain Metastasis Treated With Stereotactic Radiosurgery
Brain Metastases, AdultBrain MetastasesBrain Cancer
Baptist Health South Florida46 enrolled1 locationNCT06048094
Recruiting
Phase 1Phase 2
Bevacizumab and ICIs + hSRT in Symptomatic Melanoma Brain Metastases
Melanoma Brain Metastases
Melanoma and Skin Cancer Trials Limited46 enrolled1 locationNCT06163820
Recruiting
Phase 1
Stereotactic Radiosurgery Dose Escalation for Brain Metastases
Brain Metastases
University of Utah50 enrolled1 locationNCT02390518
Recruiting
Phase 1Phase 2
Neurocognitive Decline in Patients With Brain Metastases
Brain Metastases
University of Texas Southwestern Medical Center80 enrolled1 locationNCT03508752
Recruiting
Phase 1Phase 2
Study of SHR-A1811 Combined With Pyrotinib and Bevacizumab in Advanced Breast Cancer With Brain Metastasis
Breast Cancer MetastaticBreast Cancer Brain Metastases
Fudan University74 enrolled1 locationNCT06718933