Phase 1 Brain Neoplasm Clinical Trials
10 recruitingPhase 1
What is a Phase 1 trial?
Phase 1 trials test a new treatment in a small group of people for the first time. The primary goal is to evaluate safety, determine a safe dosage range, and identify side effects. These studies typically enroll 20 to 80 participants.
Showing 1–10 of 10 trials
Recruiting
Phase 1Phase 2
Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer
Breast NeoplasmsBreast DiseasesNeoplasms+5 more
Stemline Therapeutics, Inc.73 enrolled86 locationsNCT05386108
Recruiting
Phase 1
Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain Tumors
Resectable Brain NeoplasmRecurrent Diffuse Hemispheric Glioma, H3 G34-MutantRecurrent Malignant Brain Neoplasm
University of Michigan Rogel Cancer Center11 enrolled1 locationNCT06914479
Recruiting
Phase 1
CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children
Malignant Brain NeoplasmRecurrent Malignant Brain NeoplasmRefractory Malignant Brain Neoplasm
City of Hope Medical Center18 enrolled3 locationsNCT04510051
Recruiting
Phase 1Phase 2
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
Malignant Brain NeoplasmMalignant Glioma
Stanford University46 enrolled1 locationNCT03510208
Recruiting
Phase 1
Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors
Malignant Brain NeoplasmMetastatic Malignant Neoplasm in the BrainMeningioma+1 more
Jonsson Comprehensive Cancer Center20 enrolled1 locationNCT06650163
Recruiting
Phase 1
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Primary Brain Neoplasm
M.D. Anderson Cancer Center13 enrolled1 locationNCT03830151
Recruiting
Phase 1
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
Recurrent Glioblastoma MultiformePrimary Glioblastoma MultiformeBrain Neoplasms, Malignant+1 more
AstraZeneca180 enrolled12 locationsNCT03423628
Recruiting
Phase 1
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
Breast CarcinomaUrothelial CarcinomaOvarian Carcinoma+31 more
Jonsson Comprehensive Cancer Center30 enrolled1 locationNCT07118176
Recruiting
Phase 1
Phase I Study of JYP0322 in ROS1 Fusion-Positive Solid Tumors
Lung NeoplasmsBrain NeoplasmsProtein Kinase Inhibitors+1 more
Guangzhou JOYO Pharma Co., Ltd101 enrolled1 locationNCT06128148
Recruiting
Phase 1Phase 2
Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma
Brain TumorBrain CancerGlioblastoma+4 more
Northwell Health33 enrolled1 locationNCT02861898